The role of tumor epithelial-mesenchymal transition and macrophage crosstalk in cancer progression
Current Osteoporosis Reports, 2023•Springer
Abstract Purpose of Review The purpose of this review is to summarize the recently
published findings regarding the role of epithelial to mesenchymal transition (EMT) in tumor
progression, macrophages in the tumor microenvironment, and crosstalk that exists between
tumor cells and macrophages. Recent Findings EMT is a crucial process in tumor
progression. In association with EMT changes, macrophage infiltration of tumors occurs
frequently. A large body of evidence demonstrates that various mechanisms of crosstalk …
published findings regarding the role of epithelial to mesenchymal transition (EMT) in tumor
progression, macrophages in the tumor microenvironment, and crosstalk that exists between
tumor cells and macrophages. Recent Findings EMT is a crucial process in tumor
progression. In association with EMT changes, macrophage infiltration of tumors occurs
frequently. A large body of evidence demonstrates that various mechanisms of crosstalk …
Purpose of Review
The purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal transition (EMT) in tumor progression, macrophages in the tumor microenvironment, and crosstalk that exists between tumor cells and macrophages.
Recent Findings
EMT is a crucial process in tumor progression. In association with EMT changes, macrophage infiltration of tumors occurs frequently. A large body of evidence demonstrates that various mechanisms of crosstalk exist between macrophages and tumor cells that have undergone EMT resulting in a vicious cycle that promotes tumor invasion and metastasis.
Summary
Tumor-associated macrophages and tumor cells undergoing EMT provide reciprocal crosstalk which leads to tumor progression. These interactions provide potential targets to exploit for therapy.
Springer
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