This article reviews findings from a wide range of scientific disciplines in exploring the idea that the mind develops at the interface between human relationships and the unfolding structure and function of the brain. Recent discoveries from a number of independent fields, including those of developmental psychology and cognitive neuroscience, can be synthesized into an integrated framework for understanding how the brain gives rise to mental processes and is directly shaped by interpersonal experiences. This “interpersonal neurobiology” (Siegel, 1999) presents an integrated view of how human development occurs within a social world in transaction with the functions of the brain that give rise to the mind. This framework suggests some basic principles for conceptualizing the essential experiential ingredients that may facilitate the development of the mind, emotional well‐being, and psychological resilience during early childhood and perhaps throughout the lifespan. At the core of these processes is a fundamental mechanism of integration which can be seen at a variety of levels, from the interpersonal to the neurological. Integration may be conceptualized as the basic process that secure attachments facilitate in promoting psychological well‐being. This article will summarize these concepts and offer some ideas about their implications for practice and future investigations. ©2001 Michigan Association for Infant Mental Health.