Among the different families of plant alkaloids,(-)-roemerine, an aporphine type, was recently
shown to possess significant antibacterial activity in Escherichia coli. Based on the
increasing demand for antibacterials with novel mechanisms of action, the present work
investigates the potential of the plant-derived alkaloid (-)-roemerine as an antibacterial in E.
coli cells using microarray technology. Analysis of the genome-wide transcriptional
reprogramming in cells after 60 min treatment with 100 μg/mL (-)-roemerine showed …

Among the different families of plant alkaloids,(-)-roemerine, an aporphine type, was recently
shown to possess significant antibacterial activity in Escherichia coli. Based on the
increasing demand for antibacterials with novel mechanisms of action, the present work
investigates the potential of the plant-derived alkaloid (-)-roemerine as an antibacterial in E.
coli cells using microarray technology. Analysis of the genome-wide transcriptional
reprogramming in cells after 60 min treatment with 100 mu g/mL (-)-roemerine showed …