Treatment outcome after linac-based radiosurgery in cerebral arteriovenous malformations: retrospective analysis of factors affecting obliteration

A Zabel, S Milker-Zabel, P Huber… - Radiotherapy and …, 2005 - Elsevier
PURPOSE: We investigated patient outcome and factors affecting obliteration rate after
radiosurgery in cerebral arteriovenous malformations (AVM). MATERIAL AND METHODS:
We have treated 110 patients with cerebral AVM with linac-based radiosurgery (RS). AVM
classification according Spetzler–Martin was 17 patients grade I (15%), 39 grade II (36%),
41 grade III (37%), 12 grade IV (11%) and 1 grade V (1%). Median single dose was 18Gy.
Mean treatment volume was 4.7 cc (range, 0.1–24.0 cc). Fifty-two patients experienced …

Treatment outcome after linac-based radiosurgery in cerebral arteriovenous malformations (AVM): Factors affecting obliteration

A Zabel, S Milker-Zabel, D Schulz-Ertner… - International Journal of …, 2004 - redjournal.org
Results As a whole, actuarial partial obliteration rate (PO) was 89% and 99% after 2 and 3
years, respectively. And actuarial complete obliteration rate (CO) was 41% after 2 years and
67% after 3 years. CO rate was significantly higher in AVM< 3 cm diameter (73% vs. 65%
after 3 years, p= 0.07) and in patients with Spetzler grade I, II, VI vs. III and IV (70% vs. 50%
after 3 years, p= 0.06). The number of feeders was significantly associated with obliteration
rate. CO was significantly higher in AVM with only one feeder vs. multiple feeders (p= 0.03) …
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