Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats
NO Al-Harbi, F Imam, MM Al-Harbi… - Journal of the renin …, 2015 - journals.sagepub.com
Journal of the renin-angiotensin-aldosterone system, 2015•journals.sagepub.com
Introduction: Tacrolimus is frequently used as immunosuppressive agent in organ
transplantation but its clinical use is limited due to its marked nephrotoxicity. Materials and
methods: Male Wistar albino rats weighing 150–200 g (10–12 weeks old) were used.
Animals were divided into four groups. Group 1 served as control group and received
normal saline, group 2 served as toxic group and received 2 mg/kg tacrolimus ip, group 3
served as treatment group and received 2 mg/kg tacrolimus ip followed by 2 mg/kg aliskiren …
transplantation but its clinical use is limited due to its marked nephrotoxicity. Materials and
methods: Male Wistar albino rats weighing 150–200 g (10–12 weeks old) were used.
Animals were divided into four groups. Group 1 served as control group and received
normal saline, group 2 served as toxic group and received 2 mg/kg tacrolimus ip, group 3
served as treatment group and received 2 mg/kg tacrolimus ip followed by 2 mg/kg aliskiren …
Introduction
Tacrolimus is frequently used as immunosuppressive agent in organ transplantation but its clinical use is limited due to its marked nephrotoxicity.
Materials and methods
Male Wistar albino rats weighing 150–200 g (10–12 weeks old) were used. Animals were divided into four groups. Group 1 served as control group and received normal saline, group 2 served as toxic group and received 2 mg/kg tacrolimus i.p., group 3 served as treatment group and received 2 mg/kg tacrolimus i.p. followed by 2 mg/kg aliskiren orally and group 4 served as drug per se group and received 2 mg/kg aliskiren orally. Tacrolimus-induced nephrotoxicity was assessed biochemically and histopathologically.
Results
Treatment with aliskiren decreased the tacrolimus-induced changes in biochemical markers of nephrotoxicity such as blood urea nitrogen and creatinine. Aliskiren also attenuated the effects of tacrolimus on oxidative stress parameters such as malondialdehyde, reduced glutathione and catalase. Histopathological and ultrastructural studies showed that aliskiren attenuated tacrolimus-induced renal damage.
Conclusion
These results suggest that aliskiren has protective effects against tacrolimus-induced nephrotoxicity; implying that renin inhibitor may counteract nephrotic syndrome associated with immunosuppressant use.
Sage Journals以上显示的是最相近的搜索结果。 查看全部搜索结果