Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma
WC Lin, FS Hsu, KL Kuo, SH Liu, CT Shun… - Journal of Molecular …, 2018 - Springer
In this study, we aimed to investigate the antitumor effects of trichostatin A (TSA), an
antifungal antibiotic that inhibits histone deacetylase (HDAC) family of enzymes, alone or in
combination with anyone of the three chemotherapeutic agents (cisplatin, gemcitabine, and
doxorubicin) for the treatment of human urothelial carcinoma (UC). Two high-grade human
UC cell lines (T24 and NTUB1) were used. Cytotoxicity and apoptosis were assessed by
MTT assay and flow cytometry, respectively. The expression of phospho-c-Raf, phospho …
antifungal antibiotic that inhibits histone deacetylase (HDAC) family of enzymes, alone or in
combination with anyone of the three chemotherapeutic agents (cisplatin, gemcitabine, and
doxorubicin) for the treatment of human urothelial carcinoma (UC). Two high-grade human
UC cell lines (T24 and NTUB1) were used. Cytotoxicity and apoptosis were assessed by
MTT assay and flow cytometry, respectively. The expression of phospho-c-Raf, phospho …
Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma
L Wei-Chou, FS Hsu, K Kuan-Lin… - Journal of …, 2018 - search.proquest.com
In this study, we aimed to investigate the antitumor effects of trichostatin A (TSA), an
antifungal antibiotic that inhibits histone deacetylase (HDAC) family of enzymes, alone or in
combination with anyone of the three chemotherapeutic agents (cisplatin, gemcitabine, and
doxorubicin) for the treatment of human urothelial carcinoma (UC). Two high-grade human
UC cell lines (T24 and NTUB1) were used. Cytotoxicity and apoptosis were assessed by
MTT assay and flow cytometry, respectively. The expression of phospho-c-Raf, phospho …
antifungal antibiotic that inhibits histone deacetylase (HDAC) family of enzymes, alone or in
combination with anyone of the three chemotherapeutic agents (cisplatin, gemcitabine, and
doxorubicin) for the treatment of human urothelial carcinoma (UC). Two high-grade human
UC cell lines (T24 and NTUB1) were used. Cytotoxicity and apoptosis were assessed by
MTT assay and flow cytometry, respectively. The expression of phospho-c-Raf, phospho …
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