Because of its severe side effects and variable efficacy, the current treatment for Chagas
disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents
for the treatment of this infection. Recently, our group reported the antiproliferative activity
and morphological alterations in epimastigotes and intracellular amastigotes of
Trypanosoma cruzi treated with eupomatenoid-5, a neolignan isolated from leaves of Piper
regnellii var. pallescens. Here, we demonstrate that eupomatenoid-5 exhibited activity …