Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum
In addition to sitosterol, syringaldehyde, 3, 4, 5-trimethoxybenzoic acid, isoelemicin and
grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and
characterized as rel-(7R, 8R, 7′ R, 8′ R)-3′, 4′-methylenedioxy-3, 4, 5, 5′-
tetramethoxy-7, 7′-epoxylignan and rel-(7R, 8R, 7′ R, 8′ R)-3, 4, 3′, 4′-
dimethylenedioxy-5, 5′-dimethoxy-7, 7′-epoxylignan on the basis of spectroscopic data,
including 2D NMR spectrometric techniques. Their in vitro activity were determined against …
grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and
characterized as rel-(7R, 8R, 7′ R, 8′ R)-3′, 4′-methylenedioxy-3, 4, 5, 5′-
tetramethoxy-7, 7′-epoxylignan and rel-(7R, 8R, 7′ R, 8′ R)-3, 4, 3′, 4′-
dimethylenedioxy-5, 5′-dimethoxy-7, 7′-epoxylignan on the basis of spectroscopic data,
including 2D NMR spectrometric techniques. Their in vitro activity were determined against …
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