Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA …
L Benbrahim-Tallaa, RA Waterland… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Aberrant DNA methylation is common in carcinogenesis. The typical pattern
appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1,
inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or
3b causes gene-specific hypermethylation. Objectives During cadmium-induced malignant
transformation, an unusual pattern of genomic hypermethylation occurred that we studied to
provide insight into the roles of specific DNMTs in oncogenesis. Methods Gene expression …
appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1,
inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or
3b causes gene-specific hypermethylation. Objectives During cadmium-induced malignant
transformation, an unusual pattern of genomic hypermethylation occurred that we studied to
provide insight into the roles of specific DNMTs in oncogenesis. Methods Gene expression …
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