Vascular endothelial growth factor expression is increased in renal cell carcinoma
PURPOSE: To compare the expression of VEGF in renal cell carcinoma (RCC) and normal
kidney. Materials and Methods: RT-PCR and Western blot analysis were performed on
tumour and normal adjacent kidney collected from 31 patients (29 RCC and 2 oncocytomas)
as well as proliferating vascular endothelial cells (VEC) in culture. RESULTS: Expression of
3 VEGF isoforms was detected in normal renal parenchyma and all ROC by RT-PCR, but
was not apparent in proliferating VEC. In 27 RCC, Western blot analysis demonstrated 3-37 …
kidney. Materials and Methods: RT-PCR and Western blot analysis were performed on
tumour and normal adjacent kidney collected from 31 patients (29 RCC and 2 oncocytomas)
as well as proliferating vascular endothelial cells (VEC) in culture. RESULTS: Expression of
3 VEGF isoforms was detected in normal renal parenchyma and all ROC by RT-PCR, but
was not apparent in proliferating VEC. In 27 RCC, Western blot analysis demonstrated 3-37 …
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