Objective: Although ventilation with small tidal volumes is recommended in patients with
established acute lung injury, most others receive highly variable tidal volume aimed in part
at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury,
which develops after the initiation of mechanical ventilation, is associated with known risk
factors for ventilator-induced lung injury such as ventilation with large tidal volume. Design:
Retrospective cohort study. Setting: Four intensive care units in a tertiary referral center …