When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function
D Geng, L Zheng, R Srivastava… - Blood, The Journal …, 2010 - ashpublications.org
Emerging reports reveal that activating Toll-like receptor-2 (TLR2)–MyD88 signals in CD8 T
lymphocytes enhances cytokine production and cytotoxicity; however, the signaling pathway
remains undefined. In the present study, we examined the physiologic significance and
molecular mechanisms involved in this process. We found that TLR2 engagement on T-cell
receptor transgenic CD8 OT-1 T cells increased T-bet transcription factor levels
consequently, augmenting effector transcript and protein levels both in vivo and in vitro. In …
lymphocytes enhances cytokine production and cytotoxicity; however, the signaling pathway
remains undefined. In the present study, we examined the physiologic significance and
molecular mechanisms involved in this process. We found that TLR2 engagement on T-cell
receptor transgenic CD8 OT-1 T cells increased T-bet transcription factor levels
consequently, augmenting effector transcript and protein levels both in vivo and in vitro. In …
When Toll-like receptor and T-cell receptor signals collide: A mechanism for enhanced CD8 T-cell effector function (136.11)
D Geng, L Zheng, N Asprodites… - The Journal of …, 2010 - journals.aai.org
Emerging reports reveal that activating toll-like receptor-2 (TLR)-MyD88 signals in CD8 T-
lymphocytes enhances cytokine production and cytotoxicity. In the present study, we
examined the physiological-significance and molecular mechanisms involved in this
process. We found that TLR2 engagement on T-cell receptor transgenic CD8 OT-1 T-cells
increased T-bet transcription factor levels and consequently augmented effector gene
transcript and protein levels both in vivo and in vitro whereas, TLR2 agonist did not …
lymphocytes enhances cytokine production and cytotoxicity. In the present study, we
examined the physiological-significance and molecular mechanisms involved in this
process. We found that TLR2 engagement on T-cell receptor transgenic CD8 OT-1 T-cells
increased T-bet transcription factor levels and consequently augmented effector gene
transcript and protein levels both in vivo and in vitro whereas, TLR2 agonist did not …
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