Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling
Epithelial–mesenchymal transition (EMT) is a critical process for tumor invasion and
metastasis. Hypoxia may induce EMT, and upregulated β-catenin expression has been
found in various tumors. In this study, we investigate the role of β-catenin in hypoxia-induced
EMT in hepatocellular carcinoma (HCC). Induction of EMT in HCC cell lines by hypoxia was
confirmed by altered morphology, expression change of EMT-associated markers and
enhanced invasion capacity. We showed that hypoxia-induced EMT could be enhanced by …
metastasis. Hypoxia may induce EMT, and upregulated β-catenin expression has been
found in various tumors. In this study, we investigate the role of β-catenin in hypoxia-induced
EMT in hepatocellular carcinoma (HCC). Induction of EMT in HCC cell lines by hypoxia was
confirmed by altered morphology, expression change of EMT-associated markers and
enhanced invasion capacity. We showed that hypoxia-induced EMT could be enhanced by …
Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma by increasing hif-1alpha activity and decreasing …
Epithelial-mesenchymal transition (EMT) has been considered critical for tumor invasion and
subsequent metastasis. Hypoxia may induce EMT and β-catenin expression has been found
upregulated in a variety of tumors. Here, we investigated the role of β-catenin in hypoxia-
induced EMT in hepatocellular carcinoma (HCC). Hypoxia of 1.0% O2 induced EMT
completely in HepG2 and Huh-7 cell lines, which was confirmed by changed morphology,
down-regulated E-cadherin, up-regulated Vimentin, Twist and Snail expression, enhanced …
subsequent metastasis. Hypoxia may induce EMT and β-catenin expression has been found
upregulated in a variety of tumors. Here, we investigated the role of β-catenin in hypoxia-
induced EMT in hepatocellular carcinoma (HCC). Hypoxia of 1.0% O2 induced EMT
completely in HepG2 and Huh-7 cell lines, which was confirmed by changed morphology,
down-regulated E-cadherin, up-regulated Vimentin, Twist and Snail expression, enhanced …
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