[PDF][PDF] YY1 is a structural regulator of enhancer-promoter loops

AS Weintraub, CH Li, AV Zamudio, AA Sigova… - Cell, 2017 - cell.com
AS Weintraub, CH Li, AV Zamudio, AA Sigova, NM Hannett, DS Day, BJ Abraham…
Cell, 2017cell.com
There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural
interactions between gene promoters and their enhancer elements. Large DNA loops that
encompass genes and their regulatory elements depend on CTCF-CTCF interactions, but
most enhancer-promoter interactions do not employ this structural protein. Here, we show
that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer …
Summary
There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their enhancer elements. Large DNA loops that encompass genes and their regulatory elements depend on CTCF-CTCF interactions, but most enhancer-promoter interactions do not employ this structural protein. Here, we show that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression. We propose that YY1-mediated enhancer-promoter interactions are a general feature of mammalian gene control.
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