Yeast β-glucan increases etoposide sensitivity in lung cancer cell line A549 by suppressing nuclear factor erythroid 2-related factor 2 via the noncanonical nuclear …
FM Siswanto, A Tamura, R Sakuma, S Imaoka - Molecular Pharmacology, 2022 - ASPET
Etoposide is regarded as one of the main standard cytotoxic drugs for lung cancer. However,
mutations in Kelch-like ECH-associated protein 1 (Keap1), the main regulator of nuclear
factor erythroid 2-related factor 2 (Nrf2), are often detected in lung cancer and lead to
chemoresistance. Since the aberrant activation of Nrf2 enhances drug resistance, the
suppression of the Nrf2 pathway is a promising therapeutic strategy for lung cancer. We
herein used the human lung adenocarcinoma cell line A549 because it harbors a Keap1 …
mutations in Kelch-like ECH-associated protein 1 (Keap1), the main regulator of nuclear
factor erythroid 2-related factor 2 (Nrf2), are often detected in lung cancer and lead to
chemoresistance. Since the aberrant activation of Nrf2 enhances drug resistance, the
suppression of the Nrf2 pathway is a promising therapeutic strategy for lung cancer. We
herein used the human lung adenocarcinoma cell line A549 because it harbors a Keap1 …
Yeast β-glucan increases etoposide sensitivity in lung cancer cell line A549 by suppressing Nrf2 via the non-canonical NF-κB pathway
FM Siswanto, A Tamura, R Sakuma, S Imaoka - Molecular Pharmacology, 2022 - ASPET
Etoposide is regarded as one of the main standard cytotoxic drugs for lung cancer. However,
mutations in Keap1, the main regulator of nuclear factor erythroid 2-related factor 2 (Nrf2),
are often detected in lung cancer and lead to chemoresistance. Since the aberrant activation
of Nrf2 enhances drug resistance, the suppression of the Nrf2 pathway is a promising
therapeutic strategy for lung cancer. We herein used the human lung adenocarcinoma cell
line A549 because it harbors a Keap1 loss-of-function mutation. A treatment with β-glucan, a …
mutations in Keap1, the main regulator of nuclear factor erythroid 2-related factor 2 (Nrf2),
are often detected in lung cancer and lead to chemoresistance. Since the aberrant activation
of Nrf2 enhances drug resistance, the suppression of the Nrf2 pathway is a promising
therapeutic strategy for lung cancer. We herein used the human lung adenocarcinoma cell
line A549 because it harbors a Keap1 loss-of-function mutation. A treatment with β-glucan, a …
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