… to cardiac fibrosis and subsequent progression to heart failure. In … ageing-related cardiac
fibrosis and the potential mechanisms responsible for fibrosis development in the ageing heart. …

… that defective fibrous tissue deposition in senescent infarcted hearts may be due to
impaired responses of aged mouse fibroblasts to growth factor stimulation. Young mouse …

… Aging is an important predisposing factor common for fibrotic heart … aged heart and lung
and have been shown to play a crucial role in cardiac fibrosis and idiopathic pulmonary fibrosis. …

… heart during aging. The amount of replacement and interstitial fibrosis in these hearts was
… In conclusion, the excessive fibrosis observed in the aged myocardium is determined by a …

… of cardiac fibrosis in various myocardial diseases, including myocardial infarction, heart failure
… ejection fraction, genetic cardiomyopathies, and diabetic heart disease. Development of …

… aged heart is characterized by fibrotic remodelling, but the mechanisms responsible for this
are incompletely understood. Furthermore, studies using aged … indicative of cardiac fibrosis, …

… More in general, the possible reduction of abnormalities in ageing hearts indicates cardiac
microvascular endothelial cells as a target for a possible therapeutic intervention [51] and …

… healing or in the aged heart. Both events play a crucial role in cardiac fibrosis, which is …
deposition of collagens that is induced by activated cardiac fibroblasts [30]. Additionally, an …

… activity, and these could be relevant in the ageing heart. In summary, there is evidence for
reduced postreceptor responsiveness of the aged heart to [3adrenergic stimulation. There is …

… In the heart, early cardiac fibroblast senescence after … excessive fibrosis; however, in
non-infarcted models of cardiac fibrosis, … as one of the drivers of cardiac fibrosis in the aged heart. …