… BRAF V600E causes upregulation of tissue inhibitor of … invasion in papillary thyroid carcinoma
(PTC). Hypoxia-inducible factor-1α (HIF-1α) is regulated by hypoxia and also by the BRAF-…

… the aggressive tumor behavior of BRAF+ PTC. The question arises whether BRAF mutation
plays a role as a prognostic marker, and how we should deal with BRAF+ tumors. This issue …

… , it may not be practical to generally recommend aggressive treatment for BRAF mutation-…
patent related to BRAF V600E mutation in thyroid cancer. No other disclosures are reported. …

… BRAF mutation in thyroid cancer occurs only in PTC and PTC-derived anaplastic … that tumors
with BRAF V600E mutation were almost twice as likely (RR = 1.79) as those with BRAF wild-…

… correlate with BRAF V600E mutation status,16, 25 however, our data did not corroborate
this. Additionally, BRAF V600E mutation status was not found to be associated with aggressive …

… a mutation of the BRAF oncogene is the most common genetic alteration found in papillary
thyroid carcinoma (… PTC is more aggressive because of its association with BRAF mutation, as …

… , together with the clinical aggressiveness associated with some … We do not know if this may
also be true for BRAF mutations … the mutation in PTCs that have extended beyond the thyroid …

… In the current study, 95 specimens of thyroid tumors were subjected to BRAF mutation
analysis. The clinicopathological findings of all the specimen is presented in Table-1. The median …

… In the present study, a patient with co-existence of BRAF V600E and GRIN2A L649W
mutations had aggressive features such as tracheal invasion and bilateral neck lymph node …

… Two recent meta-analyses showed an overall association between BRAF status and
aggressive disease features and called for tailoring treatment plans in patients accordingly. In this, …