… antifungal agent which is not freely soluble in water. The clinical use of amphotericin B is
limited by nephrotoxicity and poor water solubility, … to increase the solubility of amphotericin B. …

… Although formation and solubility enhancement of itraconazole by forming hydrochloride salt
… procedures and were characterized in terms of solubility and dissolution rate enhancement. …

… antifungal activity study revealed that the formation of KTZ OXA and KTZ FUMA did not alter
the therapeutic activity as an antifungal agent. … The reasons for solubility enhancement may …

… Parameters evaluated included: miscibility, solubility and emulsion … Antifungal activity was
assessed by organ CFU … and intestinal fluids and antifungal activity without renal toxicity in rats …

… Ketoconazole (KTZ) is an active triazole antifungal agent used against variety of fungal …
solubility [4]. Salt formation has been the commonest approach of enhancing aqueous solubility, …

… efficacy of several azole antifungal drugs while toxicity limits … drug aqueous solubility,
bioavailability and antifungal efficacy… of antifungal agents whilst maintaining or enhancing their …

… Poloxamers are amphiphilic block copolymers that increase drug solubility by forming …
water solubility increment of GF by poloxamer 407 (P407) and its effect on the antifungal activity …

… showed that the enhancement of antifungal activity may be … drugs, enhancing water uptake
and antifungal activity [14]. The … reduce the solubility of hydrophobic antifungal agents such …

… active lipophilic, poorly soluble at physiological pH broad-spectrum antifungal agent [111].
It … The enhanced antifungal properties on conjugation with nanoparticles is attributed to the …

Nystatin is an antifungal molecule with a remarkable yet squandered versatility. In this review,
its mechanism of action is explored, along with its extensive action spectrum and toxicity. A …