… translocation, Nrf2 binds to cognate antioxidant response elements (AREs) to transcribe … -1
(HO-1), with detoxification and antioxidant functions, respectively. Exposure of cells directly to …

… , the small Mafs, to bind genomic antioxidant/electrophile response elements (ARE/EpREs)
to … 4B) to test if activation is mediated through these elements. Activation was drastically …

… Inactivation of KEAP1 by oxidative stress or electrophilic chemicals allows NRF2 to activate
transcription through binding to antioxidant response elements (AREs) and recruiting histone …

… generate highly ultrasensitive NRF2 activation and antioxidant gene induction. … antioxidant
response elements (ARE) in the promoters of a battery of target genes including antioxidant …

… that employing a strategy of screening Nrf2 activators on the basis of maximizing residence
… poor inducers of the antioxidant response element-linked transcriptional response. A more …

… activator, BTZO-1, we found macrophage migration inhibitory factor (MIF) as a new regulator
of antioxidant response element- (… oxidative insults via ARE activation in animal models with …

… Nrf2 binds to conserved antioxidant response elements (AREs) in the promoters of target …
In this study, experiments with reporter constructs showed that the prototypical Nrf2 activator tert…

… 2–related factor 2, which binds to the antioxidant response element (ARE) in the promoter of
… covalently modified by electrophiles which leads to activation of ARE-dependent genes. To …

… or by inhibiting their metabolic activation, thereby suppressing … of phase II detoxifying and
antioxidant enzymes, such as the … is regulated by antioxidant response elements (AREs) under …

… Therefore, it is possible that ROS generated during metabolic activation of xenobiotics and
antioxidants may lead to the increased expression and/or modification of Nrf and Jun proteins …