A genomic screen for activators of the antioxidant response element
Y Liu, JT Kern, JR Walker, JA Johnson… - Proceedings of the …, 2007 - National Acad Sciences
… In humans, the antioxidant response element (ARE) regulates the expression of a number
of cytoprotective antioxidant enzymes and scavengers, which contribute to the endogenous …
of cytoprotective antioxidant enzymes and scavengers, which contribute to the endogenous …
[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
… response elements (AREs), which play a critical role in redox … profiling and Nrf2 activator
screening. The complexity of AREs … oxidative stress as a consequence of genetic predisposition. …
screening. The complexity of AREs … oxidative stress as a consequence of genetic predisposition. …
Identification of polymorphic antioxidant response elements in the human genome
X Wang, DJ Tomso, BN Chorley, HY Cho… - Human molecular …, 2007 - academic.oup.com
… Then we mapped SNPs to nearby genes using chromosomal positions and transcription
start site (TSS) information from NCBI dbSNP and Genomes databases. In this screen for SNPs …
start site (TSS) information from NCBI dbSNP and Genomes databases. In this screen for SNPs …
Functional antioxidant responsive elements
WW Wasserman, WE Fahl - Proceedings of the National …, 1997 - National Acad Sciences
… A screen of the GenBank database with our new, functional ARE consensus sequence …
developed a systematic map of SCD effects on gene function by analyzing genome-wide ... …
developed a systematic map of SCD effects on gene function by analyzing genome-wide ... …
Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach
SJ Shukla, R Huang, SO Simmons… - Environmental …, 2012 - ehp.niehs.nih.gov
… The antioxidant response element (ARE) signaling pathway plays an important role in the …
Objectives: We used cell-based reporter methods and informatics tools to efficiently screen a …
Objectives: We used cell-based reporter methods and informatics tools to efficiently screen a …
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes
F Katsuoka, H Motohashi, T Ishii… - … and cellular biology, 2005 - Am Soc Microbiol
… While small Maf proteins have been suggested to be essential for the Nrf2-mediated activation
of antioxidant response element (ARE)-dependent genes, the extent of their requirement …
of antioxidant response element (ARE)-dependent genes, the extent of their requirement …
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
T Nguyen, PJ Sherratt, CB Pickett - Annual review of …, 2003 - annualreviews.org
… to electrophilic compounds and phenolic antioxidants. Induction of these … , the antioxidant
response element or ARE, found in the promoter of the enzyme's gene. The transcription factor …
response element or ARE, found in the promoter of the enzyme's gene. The transcription factor …
Genome-wide identification and analysis of Nrf2 binding sites–Antioxidant response elements in zebrafish
A Raghunath, R Nagarajan, K Sundarraj… - Toxicology and Applied …, 2018 - Elsevier
… each antioxidant gene. Here, we report the AREs of Nrf2 target genes and in the genome of
… approaches employed in this study limit or minimize the number of experimental screens. …
… approaches employed in this study limit or minimize the number of experimental screens. …
High-throughput characterization of mutations in antioxidant responsive elements
A Chou - 2008 - open.library.ubc.ca
… a large screen of promoter activity in 16 cell lines on all predicted promoters in the 1% of the
human genome … function has been a focus of recent efforts to annotate vertebrate genomes. …
human genome … function has been a focus of recent efforts to annotate vertebrate genomes. …
[HTML][HTML] Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
M Ohtsuji, F Katsuoka, A Kobayashi, H Aburatani… - Journal of Biological …, 2008 - ASBMB
… Hepatocyte-specific Disruption of the Nrf1 Gene—129Sv mouse Nrf1 genomic DNA was
isolated … From PCR screening, we identified one clone that carried a homozygously recombined …
isolated … From PCR screening, we identified one clone that carried a homozygously recombined …
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