Regulation of the Nrf2–Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases

NF Villeneuve, A Lau, DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
… The main function of Nrf2 is to activate the antioxidant response and induce transcription of
… a specific DNA sequence, called the antioxidant response element (ARE), that is required for …

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

Z Sun, S Zhang, JY Chan, DD Zhang - Molecular and cellular …, 2007 - Taylor & Francis
… One of the major cellular antioxidant responses is mediated by the transcription factor Nrf2.
… to the antioxidant response element (ARE) present in the promoters of many antioxidant and …

[HTML][HTML] Antioxidant responses related to temozolomide resistance in glioblastoma

JA Campos-Sandoval, MC Gómez-García… - Neurochemistry …, 2021 - Elsevier
… revealed a broad constellation of epigenetic and genetic (mutations, deletions, amplifications
and … genes containing ARE (antioxidant response element) regulatory sequences in their …

[图书][B] Analysis of antioxidant responsive gene expression changes by thioredoxin system inhibitors and hypoxia

AE Coon - 2006 - search.proquest.com
… is made up of DNA, which is the blueprint for all of the genes in our genome. However, not
… the antioxidant response element (ARE) and the expression of antioxidant genes. In the first …

[PDF][PDF] Nrf2 Transcriptionally Activates the mafG Gene through an Antioxidant Response Element

ST Fumiki Katsuokai, H Motohashi, JD Engel - injury, 1999 - mhlw-grants.niph.go.jp
… The mice used in this study were on a mixed genetic background of 129Sv.J and ICR, Mouse
Embryonic Fibroblasts (MEF)–MEFs were prepared from individual embryos at. embryonic …

Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes

K Loesch, S Galaviz, Z Hamoui, R Clanton, G Akabani… - PLoS …, 2015 - journals.plos.org
… It is not surprising that genes necessary for “mitochondrial organization” and antioxidant
response (Nrf1 and Prdx3) might be required for cell survival after radiation stress. It also makes …

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

A Loboda, M Damulewicz, E Pyza, A Jozkowicz… - Cellular and molecular …, 2016 - Springer
antioxidant and phase II detoxification responses in mammals [1, 2]. The discovery of the
antioxidant response element (ARE) … In this species, due to the whole genome duplication such …

NRF2, a transcription factor for stress response and beyond

F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
… Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of … as
well as other bZip proteins to recognize antioxidant response elements (ARE) for activation of …

Evolution shapes the gene expression response to oxidative stress

R Siauciunaite, NS Foulkes, V Calabrò… - International journal of …, 2019 - mdpi.com
antioxidant response element ARE sequence (ARE; 5′- A / G TGA C / G NNNGC A / G -3′)
located in the promoter regions of antioxidantGenetic screens for circadian clock mutants …

[PDF][PDF] Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

FD Johnson, J Ferrarone, A Liu, C Brandstädter… - Cell reports, 2022 - cell.com
… a genome-wide CRISPR loss-of-function screen, we confirmed that the effects of LCS3 are
related to antioxidant response and … (SILAC) B Antioxidant response element reporter assay B …