The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
TH Rushmore, MR Morton, CB Pickett - Journal of Biological Chemistry, 1991 - Elsevier
… is responsive to hydrogen peroxide and phenolic antioxidants that undergo redox cycling.
These latter data suggest that the ARE is responsive … (1) and phenolic antioxidants (2). One of …
These latter data suggest that the ARE is responsive … (1) and phenolic antioxidants (2). One of …
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
K Itoh, N Wakabayashi, Y Katoh, T Ishii… - Genes & …, 1999 - genesdev.cshlp.org
… Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated …
binding to its evolutionarily conserved amino-terminal regulatory domain. The closest …
binding to its evolutionarily conserved amino-terminal regulatory domain. The closest …
[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
… elements of phase II genes. The dynamic expression of phase II genes is regulated by the
transcriptional regulatory element called antioxidant response element … elements of antioxidant…
transcriptional regulatory element called antioxidant response element … elements of antioxidant…
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
… the expression of these genes through the antioxidant responsive element (ARE), whilst
bifunctional inducers act through the ARE as well as the xenobiotic responsive element (XRE) [1]…
bifunctional inducers act through the ARE as well as the xenobiotic responsive element (XRE) [1]…
Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA–(antioxidant response elements) and mRNA (iron responsive elements) sequences
EC Theil - Journal of inorganic biochemistry, 2006 - Elsevier
… (ARE-antioxidant response element) and mRNA (IRE-iron responsive element) structures. …
Iron responsive elements are very similar (65–80% sequence identity), but each mRNA has …
Iron responsive elements are very similar (65–80% sequence identity), but each mRNA has …
Molecular mechanisms of Nrf2‐mediated antioxidant response
W Li, AN Kong - … : Published in cooperation with the University …, 2009 - Wiley Online Library
… of cellular antioxidant defense is implied in the etiology of diverse diseases, including cancer
4, 5. Gene knockout mice deficient in antioxidant response … of the antioxidant response may …
4, 5. Gene knockout mice deficient in antioxidant response … of the antioxidant response may …
[HTML][HTML] A small-molecule inducer of the antioxidant response element
… a host of protective enzymes by binding to the antioxidant response element (ARE). The
electrophilic … probes for investigating the molecular details of the cellular antioxidant response. …
electrophilic … probes for investigating the molecular details of the cellular antioxidant response. …
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD (P) H: quinone oxidoreductase1 …
S Dhakshinamoorthy, AK Jaiswal - Oncogene, 2001 - nature.com
… Antioxidant response element (ARE) and nuclear … enzyme genes in response to antioxidants
and xenobiotics. A … Treatment of cells with antioxidants and xenobiotics results in the …
and xenobiotics. A … Treatment of cells with antioxidants and xenobiotics results in the …
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
M Biswas, JY Chan - Toxicology and applied pharmacology, 2010 - Elsevier
… Oxidative stress activates transcription of a variety of antioxidant genes through cis-acting
sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family …
sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family …
[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress
C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
… The major regulatory domain is Neh2, which is located in the N terminus of Nrf2. The Neh2
domain contains seven lysine residues critically involved in ubiquitin conjugation [41] as well …
domain contains seven lysine residues critically involved in ubiquitin conjugation [41] as well …
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