The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

TH Rushmore, MR Morton, CB Pickett - Journal of Biological Chemistry, 1991 - Elsevier
… is responsive to hydrogen peroxide and phenolic antioxidants that undergo redox cycling.
These latter data suggest that the ARE is responsive … (1) and phenolic antioxidants (2). One of …

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

K Itoh, N Wakabayashi, Y Katoh, T Ishii… - Genes & …, 1999 - genesdev.cshlp.org
… Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated …
binding to its evolutionarily conserved amino-terminal regulatory domain. The closest …

[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications

A Raghunath, K Sundarraj, R Nagarajan, F Arfuso… - Redox biology, 2018 - Elsevier
elements of phase II genes. The dynamic expression of phase II genes is regulated by the
transcriptional regulatory element called antioxidant response elementelements of antioxidant

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

JD Hayes, M McMahon - Cancer letters, 2001 - Elsevier
… the expression of these genes through the antioxidant responsive element (ARE), whilst
bifunctional inducers act through the ARE as well as the xenobiotic responsive element (XRE) [1]…

Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA–(antioxidant response elements) and mRNA (iron responsive elements) sequences

EC Theil - Journal of inorganic biochemistry, 2006 - Elsevier
… (ARE-antioxidant response element) and mRNA (IRE-iron responsive element) structures. …
Iron responsive elements are very similar (65–80% sequence identity), but each mRNA has …

Molecular mechanisms of Nrf2‐mediated antioxidant response

W Li, AN Kong - … : Published in cooperation with the University …, 2009 - Wiley Online Library
… of cellular antioxidant defense is implied in the etiology of diverse diseases, including cancer
4, 5. Gene knockout mice deficient in antioxidant response … of the antioxidant response may …

[HTML][HTML] A small-molecule inducer of the antioxidant response element

W Hur, Z Sun, T Jiang, DE Mason, EC Peters… - Chemistry & biology, 2010 - cell.com
… a host of protective enzymes by binding to the antioxidant response element (ARE). The
electrophilic … probes for investigating the molecular details of the cellular antioxidant response. …

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD (P) H: quinone oxidoreductase1 …

S Dhakshinamoorthy, AK Jaiswal - Oncogene, 2001 - nature.com
Antioxidant response element (ARE) and nuclear … enzyme genes in response to antioxidants
and xenobiotics. A … Treatment of cells with antioxidants and xenobiotics results in the …

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

M Biswas, JY Chan - Toxicology and applied pharmacology, 2010 - Elsevier
… Oxidative stress activates transcription of a variety of antioxidant genes through cis-acting
sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family …

[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress

C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
… The major regulatory domain is Neh2, which is located in the N terminus of Nrf2. The Neh2
domain contains seven lysine residues critically involved in ubiquitin conjugation [41] as well …