Base editing: precision chemistry on the genome and transcriptome of living cells
… base editors achieve analogous changes using components that target RNA. Base editors
directly convert one base or base … -dividing cells without generating excess undesired editing …
directly convert one base or base … -dividing cells without generating excess undesired editing …
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
… in living cells — is one of the most recent advances in the field of genome … cells process
base editing intermediates may additionally inform new therapeutic strategies using base editors…
base editing intermediates may additionally inform new therapeutic strategies using base editors…
Base editors: modular tools for the introduction of point mutations in living cells
M Evanoff, AC Komor - Emerging topics in life sciences, 2019 - portlandpress.com
… With dozens of base editors now reported, it is … of base editors, each with its own unique
properties and potential uses. In this perspective, we describe currently available base editors, …
properties and potential uses. In this perspective, we describe currently available base editors, …
Therapeutic base editing of human hematopoietic stem cells
… Live cell images were acquired using a Nikon Eclipse Ti inverted microscope. Image
acquisition was performed at room temperature and air in a 24-well plate. Sickled …
acquisition was performed at room temperature and air in a 24-well plate. Sickled …
Base editing of organellar DNA with programmable deaminases
… in living cells. Recently, CRISPR-free, protein-only base editors, such as double-stranded
DNA … toxin A-derived cytosine base editors (DdCBEs) and adenine base editors (ABEs), have …
DNA … toxin A-derived cytosine base editors (DdCBEs) and adenine base editors (ABEs), have …
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
… Adenine base editors (ABEs) convert targeted A•T base pairs to G•C in living cells without
requiring DSBs or donor DNA templates, and with minimal formation of indels 2 . In SCD, the …
requiring DSBs or donor DNA templates, and with minimal formation of indels 2 . In SCD, the …
Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.
HA Rees, DR Liu - Nature Reviews. Genetics, 2018 - europepmc.org
The originally published article contained errors in reference numbering throughout table 1 (DNA
base editors and their approximate editing windows) due to the unintended …
base editors and their approximate editing windows) due to the unintended …
GO: a functional reporter system to identify and enrich base editing activity
… Development of a specific cytosine base editing reporter: Cy GO To detect cytosine BE
events in real time in living cells, we sought to create a reporter that would become activated …
events in real time in living cells, we sought to create a reporter that would become activated …
Precision genome editing using cytosine and adenine base editors in mammalian cells
… editing characteristics. Here, we describe a protocol for using base editing in cultured
mammalian cells… We provide guidelines for choosing target sites, appropriate base editor variants …
mammalian cells… We provide guidelines for choosing target sites, appropriate base editor variants …
Bioorthogonally activatable base editing for on-demand pyroptosis
WSC Ngai, S Yang, X Zeng, Y Liu, F Lin… - Journal of the …, 2022 - ACS Publications
… was triggered through Me 2 Tz addition and the editing efficiency was computed as the C:…
base editing activities of BaseBAC over a 48 h time-course. We observed distinct C-to-T editing …
base editing activities of BaseBAC over a 48 h time-course. We observed distinct C-to-T editing …
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