Single-cell DNA methylation and 3D genome architecture in the human brain
… depict regional transitions alongside associated methylome … the 46 brain regions sampled
in this study, the human brain has … , particularly in subcortical regions. A more comprehensive …
in this study, the human brain has … , particularly in subcortical regions. A more comprehensive …
Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain
… -wide antagonism between these two states of cytosine modifications, supporting a role
for 5hmC in shaping the neuronal DNA methylome by promoting active DNA demethylation. …
for 5hmC in shaping the neuronal DNA methylome by promoting active DNA demethylation. …
[HTML][HTML] Spatiotemporal DNA methylome dynamics of the developing mouse fetus
… Encyclopedia of DNA Elements (ENCODE) project, we profiled 168 methylomes from 12 …
Consistent with our findings across fetal tissues, one study 42 on postnatal brain reported …
Consistent with our findings across fetal tissues, one study 42 on postnatal brain reported …
Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis
DM Marzese, RA Scolyer, JL Huynh… - Human molecular …, 2014 - academic.oup.com
… high DNA methylation level in the promoter region. However, as observed in our results,
DNA … expression level even with low HOXD9 promoter region DNA methylation level. JH-1173-…
DNA … expression level even with low HOXD9 promoter region DNA methylation level. JH-1173-…
Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study
HG Hernández, AG Sandoval-Hernández… - …, 2018 - Taylor & Francis
… analysis, mainly using susceptible neurons obtained from post mortem human brain tissues,
we selected the pyramidal cells of the SFG based on their vulnerability to degeneration, and …
we selected the pyramidal cells of the SFG based on their vulnerability to degeneration, and …
The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients
… in the associated methylation and brain volume components. X axis plots variables: CpG
markers for the methylation component and brain regions for the brain volume component. Y …
markers for the methylation component and brain regions for the brain volume component. Y …
[HTML][HTML] EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
… and DNA methylation. In summary, our study reveals EGR1 programs the brain methylome
… with TET1 providing new insight into how life experience may shape the brain methylome. …
… with TET1 providing new insight into how life experience may shape the brain methylome. …
[HTML][HTML] Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
… in mitochondrial function, brain development, and stress response. Methylome network
analysis uncovered decreased epigenetic modularity in both the brain and the germline of …
analysis uncovered decreased epigenetic modularity in both the brain and the germline of …
DNA modifications in the mammalian brain
… We then describe the profiles of different DNA modifications in the mammalian brain
genome. Finally, we discuss roles of DNA modifications in mammalian brain development and …
genome. Finally, we discuss roles of DNA modifications in mammalian brain development and …
On the outside, looking in: a review and evaluation of the comparability of blood and brain “‐omes”
DS Tylee, DM Kawaguchi… - American Journal of …, 2013 - Wiley Online Library
… They concluded that the blood–brain methylome is more closely correlated than blood–brain
gene expression values as detected by microarray (approximate r = 0.6), while reporting …
gene expression values as detected by microarray (approximate r = 0.6), while reporting …