TRIBUTE-A phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC)

RS Herbst, D Prager, R Hermann, V Miller… - Journal of Clinical …, 2004 - ascopubs.org
… as leading to death (53 erlotinib; 27 PBO). Only 5 of … Erlotinib combined with carboplatin
and paclitaxel chemotherapy did not confer a survival advantage over carboplatin and paclitaxel

TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non–small-cell lung cancer

RS Herbst, D Prager, R Hermann… - Journal of clinical …, 2005 - ascopubs.org
Erlotinib with concurrent carboplatin and paclitaxel did not confer a survival advantage over
carboplatin and paclitaxel … Never smokers treated with erlotinib and chemotherapy seemed …

Phase I, pharmacokinetic, and biological study of erlotinib in combination with paclitaxel and carboplatin in patients with advanced solid tumors

A Patnaik, D Wood, AW Tolcher, M Hamilton… - Clinical cancer …, 2006 - AACR
… of erlotinib in combination with paclitaxel and carboplatin on … pharmacokinetics of erlotinib,
paclitaxel, and carboplatin in … of erlotinib on the clearance of paclitaxel and carboplatin; (d) …

Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in …

HT Tran, RG Zinner, GR Blumenschein Jr… - Investigational new …, 2011 - Springer
erlotinib with carboplatin and paclitaxel 6). In this previous study, there was no evidence of
a pharmacokinetic interaction between paclitaxel and erlotinib, … during erlotinib treatment. …

Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: a phase II study based on surgical reassessment

SV Blank, P Christos, JP Curtin, N Goldman… - Gynecologic …, 2010 - Elsevier
… kinase inhibitor erlotinib in combination with first-line carboplatin-paclitaxel chemotherapy
in … We found no evidence that addition of erlotinib to carboplatin-paclitaxel improved the …

Paclitaxel/carboplatin plus bevacizumab/erlotinib in the first-line treatment of patients with carcinoma of unknown primary site

JD Hainsworth, DR Spigel, DS Thompson… - The …, 2009 - academic.oup.com
… use bevacizumab and erlotinib concurrently with paclitaxel and carboplatin in the … paclitaxel
and carboplatin. For patients felt to be benefiting from treatment, bevacizumab and erlotinib

Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma …

PA Jänne, X Wang, MA Socinski, J Crawford… - Journal of clinical …, 2012 - ascopubs.org
… kinase inhibitor (TKI) erlotinib is an effective treatment for … The efficacy of EGFR TKIs, including
erlotinib, is greatest in the … the role of adding erlotinib to first-line carboplatin and paclitaxel

Randomized phase II study of pulse erlotinib before or after carboplatin and paclitaxel in current or former smokers with advanced non–small-cell lung cancer

GJ Riely, NA Rizvi, MG Kris, DT Milton… - Journal of Clinical …, 2009 - ascopubs.org
… of erlotinib followed by carboplatin and paclitaxel) be compared with carboplatin and paclitaxel
… In the TRIBUTE trial, 495 former or current smokers receiving carboplatin and paclitaxel

Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results …

AN Gordon, N Finkler, RP Edwards… - International Journal of …, 2005 - ijgc.bmj.com
… rate and safety profile of erlotinib HCl (erlotinib, Tarceva™, OSI-… Thirty-four patients received
150 mg erlotinib orally once daily … Erlotinib was generally well tolerated. The most frequent …

Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines

Q Dai, YH Ling, M Lia, YY Zou, G Kroog, KK Iwata… - Clinical Cancer …, 2005 - AACR
… to erlotinib was observed in the doxorubicin-resistant human breast cancer cell line MCF-7,
paclitaxel-… The IC 50 values of erlotinib in the resistant cell lines were 2- to 20-fold lower than …