Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat
MG Cummings, PB Sotters, JH James… - Journal of …, 1976 - Wiley Online Library
… This difference may be explained by the presumed chronic elevation in brain Trp in shunts
which could be expected to result in greater accumulation of 5-HIAA as a result of chronically …
which could be expected to result in greater accumulation of 5-HIAA as a result of chronically …
Indoleamine neurons and their processes in the normal rat brain and in chronic diet‐induced thiamine deficiency demonstrated by uptake of 3H‐Serotonin
V Chan‐Palay - Journal of Comparative Neurology, 1977 - Wiley Online Library
… This study confirms the indoleamine neuronal locations in the brain stem described by the
Swedish investigators, but in addition a number of other sites in the diencephalon - several …
Swedish investigators, but in addition a number of other sites in the diencephalon - several …
Brain indoleamine 2, 3-dioxygenase contributes to the comorbidity of pain and depression
… brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism,
plays a key role in this comorbidity. We found that chronic … induced by chronic social stress…
plays a key role in this comorbidity. We found that chronic … induced by chronic social stress…
Activation of brain indoleamine 2, 3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy
W Xie, L Cai, Y Yu, L Gao, L Xiao, Q He, Z Ren… - Journal of …, 2014 - Springer
… In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme
in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior. …
in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior. …
Bacille Calmette-Guerin inoculation induces chronic activation of peripheral and brain indoleamine 2, 3-dioxygenase in mice
M Moreau, J Lestage, D Verrier… - The Journal of …, 2005 - academic.oup.com
… the brain [17]. However, the study of the pathophysiological consequences of any prolonged
alteration in TRP metabolism requires a model of chronic brain … model of chronic brain IDO …
alteration in TRP metabolism requires a model of chronic brain … model of chronic brain IDO …
Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2, 3-dioxygenase-dependent depression-like behaviors
MA Lawson, JM Parrott, RH McCusker… - Journal of …, 2013 - Springer
… Furthermore, we injected 1MT directly into the brain while Dobos and colleagues administered
1MT subcutaneously via a chronic release pellet or via injections without determining …
1MT subcutaneously via a chronic release pellet or via injections without determining …
Chronic effects of γ-interferon on quinolinic acid and indoleamine-2, 3-dioxygenase in brain of C57BL6 mice
K Saito, SP Markey, MP Heyes - Brain Research, 1991 - Elsevier
… although small increases in brain IDO activity and QUIN … chronic systemic administration
of y-IFN results in sustained increases in the activity of IDO and QUIN concentrations in brain…
of y-IFN results in sustained increases in the activity of IDO and QUIN concentrations in brain…
Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid.
SN Young, S Gauthier - Journal of Neurology, Neurosurgery & …, 1981 - jnnp.bmj.com
… indoleamine metabolism in human brain and spinal cord. Our data suggested that (1) the
blood-brain … We have also found this in depressed patients on chronic tryptophan treatment.13 …
blood-brain … We have also found this in depressed patients on chronic tryptophan treatment.13 …
Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic …
X Fu, SM Zunich, JC O'Connor, A Kavelaars… - Journal of …, 2010 - Springer
… degrading enzyme indoleamine 2,3 dioxygenase (IDO) in both the brain and periphery. IDO
… the plasma and brain of patients and animals following both acute and chronic stimulation of …
… the plasma and brain of patients and animals following both acute and chronic stimulation of …
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2, 3 …
R Fuertig, D Azzinnari, G Bergamini… - Brain, behavior, and …, 2016 - Elsevier
… effects of psychosocial stress as chronic social defeat (CSD) … tryptophan–kynurenine
catabolising enzyme indoleamine 2,3-… Nonetheless, oral IDOInh reduced blood and brain levels of …
catabolising enzyme indoleamine 2,3-… Nonetheless, oral IDOInh reduced blood and brain levels of …
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