CD4+ T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy

SI Buschow, DTSL Jansen - Cells, 2021 - mdpi.com
… CD8 + T cells. In this review, we summarize what is known about CD4 + T cells in chronic
HBV infection and discuss the importance and opportunities of including CD4 + T cells in T cell-…

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

A Ulsenheimer, JT Gerlach, NH Gruener, MC Jung… - Hepatology, 2003 - Elsevier
… proliferation followed by a rapid decline in IFN- –producing cells, corresponding to … CD4 T
cells or failure to develop a long-lasting T-helper response may contribute to chronic hepatitis

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

B Rehermann - Nature medicine, 2013 - nature.com
cells in the pathogenesis of chronic hepatitis B and C and discusses recent findings that
identify natural killer cells as regulators of T cell … causing CD4 + T cell dysfunction, CD4 + T cell

The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C

…, RM Hoffmann, MC Jung, T Gerlach… - Journal of molecular …, 1996 - Springer
CD4+ helper and CD8+ cytotoxic T cells in a substantial proportion of patients with chronic
hepatitis … an association between strong CD4+ T helper cell activity to certain hepatitis C virus …

Cytotoxic CD4+ T cells in viral hepatitis

…, C Yurdaydin, J Wiegand, T Greten… - … of viral hepatitis, 2006 - Wiley Online Library
CD4 + T cells might contribute to the histological disease activity of chronic viral hepatitis. …
The mean percentage of perforin-positive CD4 + T cells was 6.6 ± 6.4% in chronic hepatitis

TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection

H Wang, H Luo, X Wan, X Fu, Q Mao, X Xiang… - Journal of …, 2020 - Elsevier
… 1 helper (Th1) CD4 T cells, we analyzed patients’ HBV-specific CD4 T cells by intracellular
cytokine … Similar to previous reports, 3 HBV-specific CD4 T cells in patients with chronic HBV

[PDF][PDF] Interleukin‐17–producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

JY Zhang, Z Zhang, F Lin, ZS Zou, RN Xu, L Jin… - …, 2010 - Wiley Online Library
… Th17 cells, IFN-–producing CD4 T cells (Th1), IL4–producing CD4 T cells (Th2), and
FoxP3-positive CD4 T cells … All subjects clearly displayed all four of the CD4 T-cell subsets (Fig. …

Proliferative response of CD4+ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e—minus hepatitis B virus mutants

HF Lohr, W Weber, J Schlaak, B Goergen… - Hepatology, 1995 - Elsevier
… in acute exacerbations of chronic liver disease. 9-13 Low-level stimulation of CD4 ÷ T
cells in chronic hepatitis may contribute to insufficient induction of HBV-specific CTL and …

Hepatitis B virus–specific and global T-cell dysfunction in chronic hepatitis B

JJ Park, DK Wong, AS Wahed, WM Lee, JJ Feld… - Gastroenterology, 2016 - Elsevier
CD4 T cells as a marker of regulatory T cells in our study, as previously reported in chronic
hepatitis … beyond HBV-specific T cells. First, PD-1 and CTLA-4 expression was higher in total …

Decrease in hepatic CD56+ T cells and Vα24+ natural killer T cells in chronic hepatitis C viral infection

T Deignan, MP Curry, DG Doherty, L Golden-Mason… - Journal of …, 2002 - Elsevier
… + T cells and Vα24 + natural killer T cells in chronic hepatitis C … Results: CD4 + T cells bearing
αβ T cell receptors (TCR) … in livers with chronic HCV infection while CD56 + αβ T cells and …