Glycosylation in cancer: mechanisms and clinical implications

SS Pinho, CA Reis - Nature Reviews Cancer, 2015 - nature.com
glycosylation alterations compared with their non-transformed counterparts. Protein glycosylation
… This heterogeneity occurs because aberrant glycan modifications are protein-specific, …

[HTML][HTML] Evolutional and clinical implications of the epigenetic regulation of protein glycosylation

T Horvat, V Zoldoš, G Lauc - Clinical Epigenetics, 2011 - Springer
… all the genes involved in N glycosylation. Due to the absence … derives from differences in
protein glycosylation. However, … mechanisms involved in protein glycosylation are still scarce, …

[HTML][HTML] Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications

Y Wang, H Chen - Oncogene, 2023 - nature.com
… Understanding the process of protein glycosylation and its … Here, we describe the change
of protein glycosylation patterns … , and discuss the potential clinical implication of glycans for …

Role and therapeutic implications of protein glycosylation in neuroinflammation

AL Rebelo, MT Chevalier, L Russo, A Pandit - Trends in Molecular …, 2022 - cell.com
… We focus on protein glycosylation changes seen upon disease in the brain/spinal cord tissue,
and the modulation of GBP expression (particularly in immune cells) in neuroinflammatory-…

Aberrant protein glycosylation in cancer: implications in targeted therapy

JG Rodrigues, HO Duarte, CA Reis… - Biochemical Society …, 2021 - portlandpress.com
Protein glycosylation, the most abundant protein post-translational modification, is a highly
… Alterations in glycosylation pathways actively drive malignant phenotypes in cancer [2]. The …

Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

BL Duivelshof, W Jiskoot, A Beck, JL Veuthey… - Analytica chimica …, 2019 - Elsevier
… in immunogenicity and clinical efficacy of therapeutic proteins. … of glycan characterization
on therapeutic proteins, with a … to illustrate the potential clinical implications of differences in …

[HTML][HTML] Glycosylation in cervical cancer: new insights and clinical implications

Z Xu, Y Zhang, DKW Ocansey, B Wang, F Mao - Frontiers in Oncology, 2021 - frontiersin.org
… comprehension of protein glycosylation and concentrate … protein glycosylation and
concentrates on how cancer-associated glycans affect the tumor microenvironment. The implications

Glycosylation of recombinant protein therapeutics: control and functional implications

DA Cumming - Glycobiology, 1991 - academic.oup.com
… most elaborated and sophisticated of these, protein glycosylation. As a result, … of protein
glycosylation. This review seeks to summarize these studies, illustrating that protein glycosylation

Protein glycosylation in viral hepatitis-related HCC: Characterization of heterogeneity, biological roles, and clinical implications

S Zhang, X Cao, Q Gao, Y Liu - Cancer Letters, 2017 - Elsevier
Protein glycosylation is one of the most frequent and well-known … that protein glycosylation
is commonly altered in different liver diseases. However, the complexities of glycosylation in …

[HTML][HTML] Glycosylation in renal cell carcinoma: mechanisms and clinical implications

X Zhu, A Al-Danakh, L Zhang, X Sun, Y Jian, H Wu… - Cells, 2022 - mdpi.com
glycosylation is associated with differential glycosyl-transferase expression and glycosidases,
producing specific glycosylated proteins … Overall, aberrant protein glycosylation in cancer …