Integration and use of biomarkers in drug development, regulation and clinical practice: a US regulatory perspective

S Amur, FW Frueh, LJ Lesko, SM Huang - 2008 - Taylor & Francis
… Ultimately, we believe that testing for these biomarkers will greatly enhance drug therapy,
making drug products safer to use, while at the same time making efficacious outcomes more …

Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practice

RD Bruce, FL Altice, MN Gourevitch… - JAIDS Journal of …, 2006 - journals.lww.com
therapy or may lead to complications among patients whose treatment is already underway.
We therefore review the clinical … (BUP) and antiretroviral therapies and provide an approach …

Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments

VM Lauschke, L Milani, M Ingelman-Sundberg - The AAPS journal, 2018 - Springer
… In the following, we highlight selected pharmacogenomic examples that impact clinical
practice and refer to the primary references provided in Tables 2 and 3 as well as to …

Drug/device combinations for local drug therapies and infection prophylaxis

P Wu, DW Grainger - Biomaterials, 2006 - Elsevier
… a versatile, emerging clinical technology promising to … the drug-eluting stent have heralded
the entrance, and significantly, routes to FDA approval, for these devices into clinical practice. …

Personalised medicine for cancer: from drug development into clinical practice

KK Jain - Expert opinion on pharmacotherapy, 2005 - Taylor & Francis
… This variability helps to explain unpredictable responses to existing drug therapies that have
been observed so far. Largescale expression monitoring on microarrays has provided the …

Compliance with drug therapy for postmenopausal osteoporosis

D Weycker, D Macarios, J Edelsberg, G Oster - Osteoporosis International, 2006 - Springer
… Accumulating evidence suggests, however, that these agents are underutilized in clinical
practice due to low rates of prescribing among persons at high risk of fracture, and also poor …

[PDF][PDF] Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines

RJ Gralla, D Osoba, MG Kris, P Kirkbride… - Journal of Clinical …, 1999 - Citeseer
… In addition, these guidelines describe administration of therapies in clinical practice; … of
clinical trials, given that such clinical studies are designed to test innovative and novel therapies

Antiplatelet drugs: American College of Chest Physicians evidence-based clinical practice guidelines

C Patrono, C Baigent, J Hirsh, G Roth - Chest, 2008 - Elsevier
therapy, including the optimal dose of aspirin, the variable balance of benefits and hazards in
clinical settings, and the issue of interindividual variability in response to antiplatelet drugs. …

Introduction of HIV drug-resistance testing in clinical practice

R Rodríguez-Rosado, C Briones, V Soriano - Aids, 1999 - journals.lww.com
… There is no doubt that drug-resistance assays have achieved sufficient technological maturity
to be introduced into clinical practice. However, the information they provide seems to be …

Blood pressure drug therapy and electrolyte disturbances

G Liamis, H Milionis, M Elisaf - … Journal of Clinical Practice, 2008 - Wiley Online Library
… In line with clinical practice, evidence from clinical trials indicate that most hypertensive
patients need two or more drugs for adequate BP control. On the other hand, complex medication …