… In this review, we summarize what is known about the cellular recognition, ingestion, and
killing of C. neoformans and discuss the unique and remarkable features of its intracellular life, …

… In light of recent progress, we describe in this review the life cycle of C. neoformans with a
… The ability of capsulated yeast cells to proliferate both intracellularly and extracellularly in …

… Cryptococcus neoformans is a facultative intracellular fungal pathogen that causes cryptococcosis
… ), which can result in life-threatening cryptococcal meningoencephalitis. Significant …

… In order to survive in the hostile intracellular environment, Cryptococcus neoformans
secretes or enlarges its Cap, forms Mel as an antioxidant against reactive oxygen and nitrogen …

… neoformans, possibly in a form that survives through latency in the lung and can reactivate
… C. neoformans has a remarkably sophisticated intracellular survival capacities yet it is a free-…

… C. neoformans intracellular residence was associated with cytotoxicity to host phagocytic
cells. At 2 h after infection macrophages with intracellular yeast appeared intact, but by 8 h after …

… , illustrating potential roles for cryptococcal virulence factors in intracellular pathogenesis.
Following phagocytosis, phagolysosomal fusion occurs, with transfer of capsular …

… -tropic intracellular … The intracellular events after L. pneumophilia infection of amoebae
and macrophages are similar (11). Hence, we hypothesized that Cn was capable of intracellular …

Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is
considerable evidence that this microbe can damage host cells and tissues. In this essay, …

… Of the facultative intracellular pathogens, Cryptococcus neoformans has developed unique
factors that regulate pathogen invasion and dissemination based on its ability to choose …