Monogenic intestinal epithelium defects and the development of inflammatory bowel disease

G Leung, AM Muise - Physiology, 2018 - journals.physiology.org
inflammatory bowel disease (IBD) is increasing worldwide, most notably in young children.
The development of diseasedisease, including pediatric inflammatory bowel disease (IBD). …

Genetics of inflammatory bowel disease: progress and prospects

CG Mathew, CM Lewis - Human molecular genetics, 2004 - academic.oup.com
… This review will focus on some of the new developments in the genetics of IBD. Additional
information on the genetic and immunological basis of IBD can be found in other recent …

Inflammatory bowel disease: etiology, pathogenesis and current therapy

JK Ko, KK Auyeung - Current pharmaceutical design, 2014 - ingentaconnect.com
colitis (UC) and Crohn’s disease (CD) constitute the two major groups of idiopathic disorders
in inflammatory bowel disease (… in the development of inflammatory bowel disease in TCR-…

Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature

JK Hou, B Abraham, H El-Serag - Official journal of the American …, 2011 - journals.lww.com
OBJECTIVES: The incidence of inflammatory bowel disease (IBD) is increasing. Dietary
factors such as the spread of the “Western” diet, high in fat and protein but low in fruits and …

The binding specificity and selective antagonism of vedolizumab, an anti-α4β7 integrin therapeutic antibody in development for inflammatory bowel diseases

D Soler, T Chapman, LL Yang, T Wyant, R Egan… - … of Pharmacology and …, 2009 - ASPET
… with inflammatory bowel diseases. The inflammatory bowel diseases (IBDs), ulcerative
colitis (UC) and Crohn's disease (CD), are chronic diseases of the gastrointestinal (GI) tract …

Historical aspects of inflammatory bowel disease

JB Kirsner - Journal of clinical gastroenterology, 1988 - journals.lww.com
… Such important developments also involve individuals with inquiring minds, motivated by …
Thus, awareness of inflammatory bowel disease (IBD) began with single patient experiences, …

Diagnostics of inflammatory bowel disease

S Nikolaus, S Schreiber - Gastroenterology, 2007 - Elsevier
… the development of more sophisticated endoscopic and noninvasive imaging techniques
with the aim of improving the identification of complications, in particular malignant diseases

Evolving knowledge and therapy of inflammatory bowel disease

JR Korzenik, DK Podolsky - Nature reviews Drug discovery, 2006 - nature.com
… With recent advances in the understanding of its pathophysiology, inflammatory bowel
disease has become a very active area for the development of novel therapeutic agents. New …

Current theories on the causes of inflammatory bowel disease

KA Papadakis, SR Targan - Gastroenterology Clinics of North America, 1999 - Elsevier
… of ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel
diseases (… This situation may explain the development of disease onset or flare after enteric or …

Experimental models of inflammatory bowel disease

CO Elson, RB Sartor, GS Tennyson, RH Riddell - Gastroenterology, 1995 - Elsevier
… to be an important factor for the development of the colitis, which may explain why the effective
… Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. …