Expression of various genes is controlled by DNA methylation during mammalian development

M Ehrlich - Journal of cellular biochemistry, 2003 - Wiley Online Library
developmental genes [… genes during development by differential DNA methylation. There
are several caveats in studies of whether DNA methylation is a regulator of tissue-specific gene

DNA methylation

R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
… plays a critical role in silencing specific genes during development and cell differentiation.
The intrinsic mutagenicity of 5-mC, activation of proto-oncogenes through hypomethylation, …

DNA methylation in early development

TM Geiman, K Muegge - … Reproduction and Development …, 2010 - Wiley Online Library
developmental genes such as the Hox and Pax family members show preferential DNA
methylation… Though developmental changes in DNA methylation are crucial, we are only starting …

DNA methylation in early development

A Razin, R Shemer - Human Molecular Genetics, 1995 - academic.oup.com
… strongly suggest that DNA methylation is involved in embryo development. Perhaps the most
methylation changes have been observed during the early steps of embryo development. …

DNA methylation: roles in mammalian development

ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
… two developmental periods, primordial germ cell (PGC) specification and the early embryo,
in which DNA methylation … principles of DNA methylation in mammalian development and set …

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

TB Miranda, CC Cortez, CB Yoo, G Liang, M Abe… - Molecular cancer …, 2009 - AACR
… We then looked at the effects of DZNep on DNA methylation. Pyrosequencing showed that
the treatment of MCF7 cells with 5 μmol/L DZNep did not affect the levels of DNA methylation

Notes on the role of dynamic DNA methylation in mammalian development

TH Bestor, JR Edwards… - Proceedings of the …, 2015 - National Acad Sciences
… and represses genes via reversible DNA methylation. … DNA methylation does have essential
roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes

DNA methylation in animal development

RR Meehan - Seminars in cell & developmental biology, 2003 - Elsevier
… of methylation at distinct residues of the N-terminal tails of histone H3 and H4. This review
describes the role of the DNA methylation-… remodelling activities) in animal development. …

Dynamics and function of DNA methylation in plants

H Zhang, Z Lang, JK Zhu - Nature reviews Molecular cell biology, 2018 - nature.com
DNA methylation are crucial for development. In both plants and mammals, DNA methylation
is catalysed by conserved DNA … donor, whereas active DNA demethylation involves a base …

DNA methylation patterns and epigenetic memory

A Bird - Genes & development, 2002 - genesdev.cshlp.org
… The heritability of methylation states and the secondary nature of the … methylation support
the idea that DNA methylation is adapted for a specific cellular memory function in development