… pharmacokinetics of PG and its covariates in neonates following intravenous administration.
The pharmacokinetic … obtained in 62 preterm and term neonates after administration of …

… the full-term neonate possesses an intact barrier function and is similar to that of an older
child or adolescent. However, the ratio of surface area to body weight of the full-term neonate is …

… ) and OCT1 allele frequency (c) on the plasma log M/M1 observations as collected during
continuous intravenous tramadol administration in preterm and term neonates. The lower the …

… of human developmental biology is needed Citation[1–4]. In the current review, we will
focus on the developmental aspects of pharmacokinetics of drugs in neonates to illustrate the …

… on the pharmacokinetic (PK) parameters of a drug which are highly variable in … neonatal
population. This review highlights the developmental changes in preterm and full-term neonates …

… drug metabolism and elimination in preterm and term infants. Renal clearance of drugs in
preterm and term neonates is in general lower compared to that in infants and children, and it …

… approximately 80% in newborns to 60% by 1 year of age. Conversely, body fat increases
with age, from 1% to 2% in a preterm neonate to 10% to 15% in a term neonate and 20 to 25% …

… : Preterm and term newborn infants show wide interindividual variability (IIV) in pharmacokinetic
… to characterize the population pharmacokinetics of gentamicin in preterm and term …

… children and adults, and preterm neonates have an even higher value when compared to term
neonates.… 80% to 90% in preterm and 70% in term neonates, with a progressive decrease …

… of physiologically based pharmacokinetic modeling in preterm and term neonates is investigat-
… In this review, neonatal PBPK is mostly discussed for term and preterm neonates alike. …