Epigenetics and human disease: translating basic biology into clinical applications
D Rodenhiser, M Mann - Cmaj, 2006 - Can Med Assoc
… These dynamic chromatin states are controlled by reversible epigenetic patterns of DNA
methylation and histone modifications.4 Enzymes involved in this process include …
methylation and histone modifications.4 Enzymes involved in this process include …
Fetal programming: link between early nutrition, DNA methylation, and complex diseases
A Chmurzynska - Nutrition reviews, 2010 - academic.oup.com
… in DNA methylation and histone modifications. Dicer 1 deficiency in mice leads to decreased
DNA methylation, and these methylation … DNA methylation. PiRNAs are essential for the …
DNA methylation, and these methylation … DNA methylation. PiRNAs are essential for the …
DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease
DM Jeziorska, RJS Murray… - Proceedings of the …, 2017 - National Acad Sciences
… to study in detail the mechanism by which a CGI located at the α-globin locus becomes
methylated when incorporated into a newly formed transcriptional unit causing a human disease […
methylated when incorporated into a newly formed transcriptional unit causing a human disease […
DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites
M Krolevets, V Cate, JH Prochaska, A Schulz… - Clinical …, 2023 - Springer
… of knowledge on significant relationship between DNA methylation and CVD in humans.
An open-access database has been compiled of reported CpG methylation sites, genes and …
An open-access database has been compiled of reported CpG methylation sites, genes and …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
… potential insights for human disease onset and progression. In this review, we summarize
recent milestones in characterizing the human genetic basis of DNA methylation variation over …
recent milestones in characterizing the human genetic basis of DNA methylation variation over …
Stability and lability of parental methylation imprints in development and disease
S Farhadova, M Gomez-Velazquez, R Feil - Genes, 2019 - mdpi.com
… DNA methylation and histone methylation imprints, their somatic maintenance during
development… may become perturbed in concert in human disease contexts. Recent data provide …
development… may become perturbed in concert in human disease contexts. Recent data provide …
A DNA methylation fingerprint of 1628 human samples
AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
… the DNA methylation profiles for 150 … DNA methylation patterns described in human disease
have been reported for cancer, there is no reason to believe that disrupted DNA methylation …
have been reported for cancer, there is no reason to believe that disrupted DNA methylation …
De novo DNMTs and DNA methylation: novel insights into disease pathogenesis and therapy from epigenomics
S Leppert, MR Matarazzo - Current pharmaceutical design, 2014 - ingentaconnect.com
… Chromosome territory reorganization in a human disease with altered DNA methylation.
Proc Natl Acad Sci USA 2007; 104: 16546-51. [46] Hansen RS, Wijmenga C, Luo P, et al. …
Proc Natl Acad Sci USA 2007; 104: 16546-51. [46] Hansen RS, Wijmenga C, Luo P, et al. …
Crosstalk of genetic variants, allele-specific DNA methylation, and environmental factors for complex disease risk
… this mechanism of variants contributing to human disease susceptibility and inter-individual …
of each variant's role in complex human disease susceptibility. More specifically, we should …
of each variant's role in complex human disease susceptibility. More specifically, we should …
[PDF][PDF] Epigenetics and imprinting in human disease
… As described in more detail below, DNA methylation usually represses either a long ncRNA
or an insulator, which mediates the imprinting across the locus. A significant consequence of …
or an insulator, which mediates the imprinting across the locus. A significant consequence of …