… For cancer research, this is a significant issue as alterations in DNA methylation in human
cancer were first discovered in 1983 (1), and since that time, hundreds of labs have examined …

… The focus of this review is the specific epigenetic modification involving DNA methylation
(DNAm), a covalent addition of a methyl (CH 3 ) group to the nucleotide cytosine. DNAm is the …

… the development of DNMT inhibitors that do not require DNA … Although many questions
remain open, the DNA methylation … to have an impact on human disease. These classes of drugs …

… , we have been studying readers of DNA methylation, the 5-… DNA methylation in gene
regulation and cancer development, … the complexes these proteins form to treat human disease. …

… analysis, we performed epigenome analysis of human disease kidney samples at single-cell
resolution by reanalyzing open chromatin regions of over 60,000 cells, defining disease-…

… of DNA methylation, its role in neurodevelopment functions, and how assessment of DNA
hypermethylation and … This review also paves the way for the development of novel treatment …

… The hypothesis that DNA methylation changes are driving human disease and health … with
pharmacological or behavioral interventions maladaptive DNA methylation marks. As several …

… on determining associations between lead exposure and global DNA methylation; however,
such approaches preclude the identification of loci that may alter human disease risk. …

… disorders and ASD syndromes such as fragile X and Angelman syndrome have provided
initial support for epimutations in human disease etiology and a hypothesis of altered DNA …

… development of DNA methylation detection techniques, it has become possible to generate
genome-wide DNA methylation … promote the development of DNA methylation biomarkers …