DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… The two waves of DNA methylation reprogramming involve both distinct and shared … the
key reprogramming events, focusing on the important players in these processes, including DNA

DNA methylation and cellular reprogramming

DD De Carvalho, JS You, PA Jones - Trends in cell biology, 2010 - cell.com
… emphasis on DNA methylation during cellular reprogramming. Recent data suggest that
DNA methylation is a major barrier to induced pluripotent stem (iPS) cell reprogramming. The …

DNA methylation reprogramming in the germ line

DJ Lees-Murdock, CP Walsh - Epigenetics, 2008 - Taylor & Francis
Reprogramming methylation in the primordial germ cells … In addition to direct transcriptional
silencing, DNA methylation … and extent of DNA methylation reprogramming of many different …

Dynamic reprogramming of DNA methylation in the early mouse embryo

F Santos, B Hendrich, W Reik, W Dean - Developmental biology, 2002 - Elsevier
… De novo methylation was observed specifically in the inner cell mass (ICM) … reprogramming
cycle during preimplantation development. The three phases of methylation reprogramming

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

J Deng, R Shoemaker, B Xie, A Gore… - Nature …, 2009 - nature.com
… Consistent with these reports, we did not observe widespread changes of DNA methylation
during reprogramming in the CpG islands on chromosomes 12 and 20. Surprisingly, we still …

Epigenetic reprogramming of cancer cells via targeted DNA methylation

AG Rivenbark, S Stolzenburg, AS Beltran, X Yuan… - Epigenetics, 2012 - Taylor & Francis
… Cells transduced with ZF-97 SKD did not exhibit targeted DNA methylation (Fig. S1). To
determine if we could directionally target DNA methylation, we positioned the DNMT3a domain …

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

S Seisenberger, JR Peat, TA Hore… - … of the Royal …, 2013 - royalsocietypublishing.org
methylation erasure from the zygote. Deamination by AID, BER and passive demethylation
have been implicated in reprogramming … the dynamics of DNA methylation reprogramming in …

[PDF][PDF] The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells

S Seisenberger, S Andrews, F Krueger, J Arand… - Molecular cell, 2012 - cell.com
… Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs)
and preimplantation embryos, but the precise dynamics and biological outcomes are …

Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo

J Arand, M Wossidlo, K Lepikhov, JR Peat, W Reik… - Epigenetics & …, 2015 - Springer
… Our findings suggest a complex interplay between possible mechanisms of DNA methylation
reprogramming (that is, demethylation and de novo methylation) and DNA methylation

Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer

N Beaujean, J Taylor, J Gardner, I Wilmut… - Biology of …, 2004 - academic.oup.com
… of methylated DNA is abnormal in a high proportion. By correlating DNA methylation with …
that do not undergo rapid reorganization of their DNA before the first mitosis fail to develop …