Anatomy of DNA methylation signatures: Emerging insights and applications
E Chater-Diehl, SJ Goodman, C Cytrynbaum… - The American Journal of …, 2021 - cell.com
… DNA methylation (DNAm) signatures are unique patterns of DNAm alterations defined for
rare … cause a distinct neurodevelopmental disorder with a specific DNA methylation signature. …
rare … cause a distinct neurodevelopmental disorder with a specific DNA methylation signature. …
DNA methylation signatures for breast cancer classification and prognosis
M Szyf - Genome medicine, 2012 - Springer
… Here, I review the scientific basis for using DNA methylation signatures in breast cancer …
role of DNA methylation in normal gene regulation, the aberrations in DNA methylation in cancer…
role of DNA methylation in normal gene regulation, the aberrations in DNA methylation in cancer…
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …
performed epigenome-wide screening and validation to identify mortality-related DNAm …
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
ME Figueroa, S Lugthart, Y Li… - Cancer cell, 2010 - cell.com
… We show that large-scale genome-wide DNA methylation profiling reveals the existence
of distinct DNA methylation patterns in AML and identifies novel, biologically and clinically …
of distinct DNA methylation patterns in AML and identifies novel, biologically and clinically …
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DNA methylation signatures in development and aging of the human prefrontal cortex
S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
… DNA methylation is strongly associated with genotypic variants and correlates with … and
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human …
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human …
[HTML][HTML] DNA methylation signatures within the human brain
C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
… normal DNA methylation might distinguish individual brain regions. We determined the
quantitative DNA methylation … Our data suggest that DNA methylation signatures distinguish brain …
quantitative DNA methylation … Our data suggest that DNA methylation signatures distinguish brain …
DNA methylation signatures of the plant chromomethyltransferases
Q Gouil, DC Baulcombe - PLoS genetics, 2016 - journals.plos.org
… DNA methylation in plants is traditionally partitioned into CG, CHG and CHH contexts (with
H any nucleotide but G). By investigating DNA methylation … of different methylation pathways …
H any nucleotide but G). By investigating DNA methylation … of different methylation pathways …
DNA methylation signatures as biomarkers of prior environmental exposures
C Ladd-Acosta, MD Fallin - Current epidemiology reports, 2019 - Springer
… This review demonstrates the growing body of evidence connecting DNA methylation to
prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, …
prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, …
Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
H Hernandez-Vargas, MP Lambert, F Le Calvez-Kelm… - PloS one, 2010 - journals.plos.org
… Our study shows that HCC tumors exhibit specific DNA methylation signatures associated
with major risk factors and tumor progression stage, with potential clinical applications in …
with major risk factors and tumor progression stage, with potential clinical applications in …
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
S Ligthart, C Marzi, S Aslibekyan, MM Mendelson… - Genome biology, 2016 - Springer
… Furthermore, DNA methylation may also affect chromosome stability and alternative splicing,
two functional consequences of DNA methylation which we have not investigated in the …
two functional consequences of DNA methylation which we have not investigated in the …