Polyethylene glycol–polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in …

H Yang, JJ Morris, ST Lopina - Journal of colloid and interface science, 2004 - Elsevier
… According to our results, PEG arm length has a significant affect on pyrene water solubility.
Short PEG arms (eg, PEG 750) do not have much interaction between each other [26], thus …

[HTML][HTML] Preparation of pluronic/bile salt/phospholipid mixed micelles as drug solubility enhancer and study the effect of the PPO block size on the solubility of pyrene

L Wang, M Peng, Y Zhu, S Tong, X Cao… - Iranian Journal of …, 2014 - ncbi.nlm.nih.gov
… In this study, we have demonstrated that PPO chain length affect the thermodynamic properties
of Pluronic/BS/PS-MM micellization which, in turn, affect their solubilization potential for …

Influence of the introduction of a solubility enhancer on the formulation of lipidic nanoparticles with improved drug loading rates

A Malzert-Fréon, G Saint-Lorant, D Hennequin… - European Journal of …, 2010 - Elsevier
… The very interesting antineoplastic effect of these compounds belonging to the tripentone …
= 30–45%), no obvious impact of the length of the chain of fatty acids on the solubility of the …

Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain

SA Ibrahim, SK Li - International journal of pharmaceutics, 2010 - Elsevier
… is thought to be independent of its chemical structure (ie, polar head group or alkyl chain
length… studied (except UD), and suggests that the permeation enhancing effect of the enhancers

Solubility enhancers for oral drug delivery: can chemical structure manipulation be avoided?

CK Kim, JS Park - American Journal of Drug Delivery, 2004 - Springer
… therapeutic effects of poorly water-soluble drugs mainly by improving the poor solubility. …
formation may not eliminate the solubility problems of all poorly water-soluble drugs. Moreover, …

An investigation on the effect of drug physicochemical properties on the enhancement strength of enhancer: The role of drug-skin-enhancer interactions

W Xu, C Liu, Y Zhang, P Quan, D Yang… - International Journal of …, 2021 - Elsevier
… Furthermore, drug-specific molecular mechanisms of POCC enhancement effect were
explored using solubility parameters calculation, FT-IR, molecular docking, ATR-FTIR, Raman …

Effects of chemical enhancers on human epidermal membrane: structure-enhancement relationship based on maximum enhancement (Emax)

SA Ibrahim, SK Li - Journal of pharmaceutical sciences, 2009 - Elsevier
effects, (b) the relationship between the potencies and lipophilicities of these enhancers, and
(c) the feasibility of using enhancer solubility in … alkyl chain length up to C9-12 and beyond …

Time dependence of the enhancement effect of chemical enhancers: molecular mechanisms of enhancing kinetics

X Liu, P Quan, S Li, C Liu, Y Zhao, Y Zhao… - Journal of Controlled …, 2017 - Elsevier
… and the length of the hydrophobic tails. Moreover, chemical … The solubility parameter of the
enhancers was calculated using … A similar solubility parameter meant a good miscibility to …

Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement

KS Warner, SK Li, WI Higuchi - Journal of pharmaceutical sciences, 2001 - Elsevier
solubility, and this preparation was used in our solubility studies. The CS solubility ratios (solubility
in enhancer ÷ solubility in … modest effect of the enhancer alkyl group chain length on …

Formulation possibilities of a weak base with a narrow solubility range

M Venczel, I Szvoboda, B Podányi… - Crystal growth & …, 2012 - ACS Publications
… Cremophor ELP as a solubility enhancer, surfactant, and co-… -400 spectrometer using 30
pulse length and 10 s relaxation … is purely a solubility enhancement effect due to addition of …