Development of effective therapies for sepsis
M Booke, LD Traber, DL Traber - Critical care medicine, 1995 - journals.lww.com
… to study sepsis and new therapeutic approaches for sepsis, … promising new compounds for
sepsis have been developed. In … vasodilation in sepsis [14] , this new therapeutic approach is …
sepsis have been developed. In … vasodilation in sepsis [14] , this new therapeutic approach is …
Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies
NH Lyle, OM Pena, JH Boyd… - Annals of the New York …, 2014 - Wiley Online Library
… However, we suggest that a greater impediment to success in sepsis treatment is the lack
of effective host-directed therapies. To promote the development of innovative therapies, …
of effective host-directed therapies. To promote the development of innovative therapies, …
The search for effective therapy for sepsis: back to the drawing board?
DC Angus - Jama, 2011 - jamanetwork.com
… therapeutic approach to sepsis. Some obvious questions come to mind. First, is the current
understanding of the pathophysiology of sepsis … evaluation of potential therapies in need of …
understanding of the pathophysiology of sepsis … evaluation of potential therapies in need of …
Anti-inflammatory therapies in sepsis and septic shock
BD Freeman, C Natanson - Expert opinion on investigational drugs, 2000 - Taylor & Francis
… necessary to ultimately determine whether endotoxin is an effective therapeutic target in
sepsis. … will be essential to designing and testing more effective therapeutic strategies in sepsis. …
sepsis. … will be essential to designing and testing more effective therapeutic strategies in sepsis. …
[HTML][HTML] Advances in sepsis therapy
T Glück, SM Opal - Drugs, 2004 - Springer
… sepsis remains the mainstay of therapy for severe sepsis. How these new and often expensive
regimens will fit into the standard treatment approach to sepsis … relevant or cost effective. …
regimens will fit into the standard treatment approach to sepsis … relevant or cost effective. …
Optimizing antimicrobial therapy in sepsis and septic shock
A Kumar - Critical care clinics, 2009 - criticalcare.theclinics.com
… Abscesses present a series of barriers to effective therapy; antimicrobials cannot be effectively
delivered into the avascular core of abscesses or other necrotic tissue (depending on size)…
delivered into the avascular core of abscesses or other necrotic tissue (depending on size)…
Novel therapies for sepsis: a review
KJ Deans, M Haley, C Natanson… - Journal of Trauma …, 2005 - journals.lww.com
… The effects of steroids on the relative survival benefit in the nine sepsis trials of high-dose
steroids … decrease in the relative survival benefit with steroid therapy during sepsis (p =0.008). …
steroids … decrease in the relative survival benefit with steroid therapy during sepsis (p =0.008). …
Advances in the therapy for sepsis in children
MR Anderson, JL Blumer - Pediatric Clinics of North America, 1997 - Elsevier
… agonist to antagonist, for modulators of sepsis that protect from tissue damage while allowing
antimicrobial defense, and for effective therapies impacting the end organ damage of the …
antimicrobial defense, and for effective therapies impacting the end organ damage of the …
A new paradigm for the treatment of sepsis: is it time to consider combination therapy?
AS Cross, SM Opal - Annals of internal medicine, 2003 - acpjournals.org
… that we reconsider our approach to therapy for sepsis. … Furthermore, an animal model of
sepsis shows that therapy … is far more effective in preventing death than any one therapy or …
sepsis shows that therapy … is far more effective in preventing death than any one therapy or …
Pharmacoeconomic implications of new therapies in sepsis
KA Wood, DC Angus - Pharmacoeconomics, 2004 - Springer
… have the most favourable cost-effectiveness ratio. In this article, … sepsis therapies,
including a review of the costs of sepsis, new anti-sepsis strategies, and elements of cost-effectiveness …
including a review of the costs of sepsis, new anti-sepsis strategies, and elements of cost-effectiveness …
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