… This study was designed to investigate EGFR protein expression, EGFR copy number and
EGFR mutations in lung adenocarcinomas, to explore the relationship of the three markers. …

… This study examined both EGFR and KRAS mutations, and EGFR gene copy number in a
clinically selected population of patients with advanced stage lung adenocarcinoma to …

… In conclusion, lung adenocarcinoma with EGFR mutations is a distinct biological subset as
… high response rate to EGFR TKIs. Amplification of EGFR in NSCLC with EGFR mutation is …

… suggest Increased EGFR copy number was highly correlated with EGFR mutation in
adenocarcinoma. Although it is less correlated with TKI responsiveness when compared with EGFR …

… It was reported that KDM5A is required to develop a metastable chromatin state that enables
drug resistance in breast cancer (39) and lung cancer treated with EGFR-TKI (40). As far as …

… In this study, EGFR-activating mutation status and DNA copy number … in 261 lung
adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-…

… cancer, namely, the decrease in HER2 gene copy number in invasive ductal carcinoma relative
to ductal carcinoma … the possible heterogeneity of EGFR amplification in lung cancer, our …

… This study suggested that EGFR expression and gene copy number, HER2 gene copy number…
Prospective phase III trials should compare standard chemotherapy with a TKI in selected …

… The current study demonstrated that FISH analysis for EGFR gene copy number in combination
with IHC assessment for EGFR protein is a useful paradigm for selection of advanced …

… In this study, we showed that EGFR copy number increase was independently related to
short DFS in lung adenocarcinoma patients who received curative resection followed by …