… to serum albumin has influence on the pharmacokinetics of a drug. In the present study,
the mutual interaction of anticancer drug erlotinib hydrochloride with bovine serum albumin (BSA…

… The purpose of this study was to investigate the site-selective binding of erlotinib
hydrochloride (ET), a targeted anticancer drug, to bovine serum albumin (BSA) through 1H NMR, …

… Binding interactions between human serum albumin (HSA) and four approved epidermal
growth factor receptor (EGFR) inhibitors gefitinib (GEF), erlotinib (ERL), afatinib (AFA), …

… Human serum albumin (HSA) is a globular and monomeric protein in plasma that transports
… We investigated the binding interactions between erlotinib hydrochloride (Erlo) and HSA. …

… Typically, BSA was dissolved in distilled water to achieve a 5% (w/v) solution and the pH was
adjusted to 5.0 with HCl. The organic solvent was then added … Structure of serum albumin …

… of erlotinib with HSA using fluorescence UV–Vis and circular dichroism (CD) spectroscopy
to understand the carrier role of serum albumin for such compounds in blood under …

… (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug
delivery in blood. Therefore, we aim to study BSA interaction with erlotinib as an anticancer …

… Erlotinib hydrochloride salt has an equilibrium solubility of approximately 0.4 mg/mL at a pH
of approximately 2 [2,7]. Erlotinib hydrochloride … About 93% of the drug is bound to albumin …

… -erlotinib serum was obtained by immunizing mice with an antigen conjugated with bovine
serum albumin … Erlotinib hydrochloride and O-desmethyl erlotinib were obtained from AdooQ …

… erlotinib, and study its anti-cancer activity. In order to conjugate protein to ETN-4, we chosen
bovine serum albumin (… active ester 30 by first EDC·HCl coupling reaction of 29 with HOBt in …