… estimation is prone to subjective assessment, as patients as … range of bleeding frequencies
among patients with similar … an efficacy measure in patients with hemophilia with and without …

… cohort of patients who enrolled in the study may have been more likely to be adherent to
their therapy than the general hemophilia population. For the CHPS, we excluded patients and …

… hemophilia A and B, suggesting that hemophilia B patients … to reduce the frequency of infusion
as hemophilia A patients, … sample of hemophilia B respondents made the estimates of the …

… higher among hemophilia A than hemophilia B patients, and … The estimated value for this
risk factor was interpreted as the … are 0.09 fewer [because the estimate is a negative number] …

… Since current DNA techniques provide information on the grandparental origin of the patient's
X chromosome, we were twice able to estimate directly the male:female mutation ratio as …

… We estimated … hemophilia patients and detected arthropathy in 36.5%. Despite the different
methods to detect arthropathy, the rate was equal to the 36.6% of mild hemophilia patients …

… Sample size estimation was not performed due to the design of the study; therefore, all of …
in both the hemophilia A and hemophilia B patients. Table 3 shows the frequency of switches …

… to assess efficacy in hemophilia is bleeding frequency. This is … and bleeding patterns in
patients with severe hemophilia A, the … to estimate a bleeding hazard corresponding to untreated …

… and dosing frequency. Based on these attribute estimates, we calculated patients’ WTP. …
In conclusion, improvements in treatment effectiveness and dosing frequency, treatment …

… hemophilia and patients with mild to moderate hemophilia … were estimated to need the same
dose, and three patients … with no discernible difference in frequency of bleeding episodes. In …