… consequence of GATA-1 function in primitive erythroid progenitors during development. …
erythroid progenitors in the yolk sac of the GATA-1-mutant embryos, demonstrating that GATA-1 …

… Using GFP fluorescence in combination with hematopoietic surface markers, we established
a purification protocol for two erythroid progenitor fractions, referred to as burst-forming units…

… progenitors express GATA-2 at high level, and GATA-1 (and possibly … stage is erythroid
differentiation blocked in the absence of GATA-1 ? Are GATA-1- primitive and definitive erythroid …

… Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and …
hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors …

… Because GATA1 has been shown to be essential for erythropoiesis, we decided to … on
GATA1 by a lentiviral GATA1 knockdown approach. We observed that depletion of GATA1 allowed …

… This study showed that in early erythroid progenitors, heme induces the translation of RPs,
ensuring sustained globin synthesis. However, at later stages of differentiation, heme …

… 1 (Dnmt1) and maintains DNA methylation status of Gata1 locus in HSC fraction (left panel).
When HSCs are differentiated to the erythroid progenitors, Dnmt1 is released from Gata1 …

… of GATA-1 decreases after the erythroid progenitor stage (Figure 4). Since constitutive
overexpression of GATA-1 in … , 23 this down-regulation of GATA-1 must be necessary for terminal …

… A cooperative cohort of broad-spectrum and specific transcription factors regulates the
formation, survival, proliferation, and differentiation of a multipotent progenitor into the erythroid …

… Top: enrichment of 154 genes that were upregulated in T21/GATA1s as compared with
T21/WT GATA1 progenitors in myeloid versus erythroid signature genes and in megakaryocytic …