… THE zinc-finger transcription factor GATA-3 is expressed in haematopoietic cells and in the
… of GATA-3 is restricted to thymocytes and T cells. Functionally important GATA-3 binding sites …

… Here, we have demonstrated an essential role for the transcription factor GATA-3, a … Treg
cell-specific GATA-3 deletion led to a spontaneous inflammatory disorder in mice. GATA-3-null …

… The transcription factor GATA3 plays an essential role during T cell development and T …
To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding …

… The transcription factor GATA-3 is … lacking GATA-3 cannot generate early thymocytes from
common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 …

… gene expression of the GATA-3 transcription factor is significantly … The majority of GATA-3
mRNA + cells were phenotypically … of GATA-3 as a transactivator of IL-5 gene transcription, a …

… transcription factor GATA3 (GATA-binding protein 3) is up-regulated or down-regulated during
T h 2 or T h 1 cell differentiation, respectively. Furthermore, GATA3 … through which GATA3 …

… ) for the GATA-l transcription factor (Figure 1), we hypothesized that GATA-l or a GATA-1
family … Northern blot analyses demonstrated the absence of GATA-l mRNA in a variety of T cell …

… We found that the transcription factor GATA-3 was the dominant … Strikingly, GATA-3 is
required for the transcription of all Th2 … in part a consequence of the down-regulation of GATA-3. …

… These data demonstrate that GATA-3 is required for the differentiation of ILC2Ps and the
maintenance of mature ILC2s. Our data establish GATA-3 both as a transcription factor …

… transcription factor GATA3 is crucial for the differentiation of naive CD4 + T cells into T helper
2 (Th2) cells. Here, we show that deletion of Gata3 … -γ production was transcription factor T-…