… A major role of genetic factors in the risk of developing restless legs syndrome (RLS) is … In
this review we have focused on those reports describing inheritance patterns of RLS, genetic …

… At the outset of genetic studies in restless legs syndrome (… any causally-related genes or
genetic variants. The advent of … which led to the identification of first genetic risk variants for RLS. …

Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%.
It is a polygenetic disorder in which a number of variants contribute to the phenotype. …

Familial aggregation of restless legs syndrome (RLS) is well documented, 1–4 including
Ekbom’s 5 seminal description of the disorder in which he posited an autosomal dominant …

… is to comprehensively review our current knowledge about the genetics of RLS. First we will
… ongoing genetic studies. Second, we will suggest guidelines for the design of future genetic …

… Restless legs syndrome (RLS) is a common condition … the legs (which may be associated
with unpleasant leg sensations), … influenced by genetic makeup (ie, a genetic diathesis fixed at …

… Several studies on restless legs syndrome (RLS) have suggested a substantial genetic …
Despite several reports suggesting a genetic contribution to the etiology of idiopathic RLS, …

… Several studies on Restless legs syndrome (RLS) have suggested a substantial genetic …
Despite several reports suggesting a genetic contribution to the etiology of idiopathic RLS, …

… Herein, we review the current status of genetics in RLS and provide some methodological
guidelines for future research. No specific genetic mutations have yet been identified however, …

… Several approaches have been used to elucidate further the underlying genetic basis of
the disease. As a first step, candidate genes were studied. Candidate genes are those genes …