… These are the most common structural autosomal abnormalities in infertile men, affecting
1/1000 men, with a higher prevalence in oligozoospermic men (1.6%) (64). These can be …

… histological signs of dysgenesis in the testicular biopsy specimens of many infertile men. The
most severe gonadal symptoms occur in patients with genetic mutations, in whom even sex …

… Several of the mice that exhibited germline mosaicism were studied in more detail to … caused
transgenic sperm infertility. We described a similar mutation that causes transmisMale 63-7 (…

… with 9p deletion syndrome and XY gonadal dysgenesis [58]. Smaller deletions and mutations
of this gene have been identified in patients with NOA without XY gonadal dysgenesis [59]. …

… Once testes differentiate, their male endocrine function is responsible for the rest of events …
Even if the r(Y) mosaicism could be evaluated only in the peripheral blood, because gonadal …

… being attributable to male infertility. Moreover, 1–55% of infertile men have been reported to
… in mice, produce abnormal meiosis, infertility, germline MSI, and susceptibility to lymphomas …

… Our investigations focused on the detection of missense and splicing KLHL10 mutations
in male germline mRNAs obtained from semen samples of OZS infertile men. We identified …

… of germline mutations in large, multigenerational pedigrees, we found that men in the highest
quartile of age-adjusted germline … between germline mutagenesis and male subfertility, we …

… (iii) The fertility of patients showing mosaic patterns of sex chromosomes of the Klinefelter
type. Raboch, Sipova and Maly (I96I), in a study of 6oo men with sexual disturbances, found a …

… As shown along this review, spermatozoa from infertile males have a higher incidence of
chromosome abnormalities than fertile individuals. Chromosome anomalies are present in …