The effect of dabigatran on haemostasis tests: a comprehensive assessment using in vitro and ex vivo samples
R Bonar, EJ Favaloro, S Mohammed, J Sioufi… - Pathology, 2015 - Elsevier
… surgical procedures, testing may be indicated. The aim of this study was to assess findings
of haemostasis laboratory tests for one of the DOACs, dabigatran (Pradaxa), tested across a …
of haemostasis laboratory tests for one of the DOACs, dabigatran (Pradaxa), tested across a …
Impact of dabigatran on a large panel of routine or specific coagulation assays
J Douxfils, F Mullier, S Robert… - … and haemostasis, 2012 - thieme-connect.com
… (s) should be used to measure the pharmacodynamic effects of dabigatran among a range
of routine or specific tests. Testing solutions of dabigatran used in this paper were chosen to …
of routine or specific tests. Testing solutions of dabigatran used in this paper were chosen to …
Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays
TL Lindahl, F Baghaei, IF Blixter… - … and haemostasis, 2011 - thieme-connect.com
… and Quick PT INR>2 or Owren PT INR>1.5 over-dosing or accumulation of dabigatran …
assay group, display variable effects at therapeutic concentrations of dabigatran. Some of these …
assay group, display variable effects at therapeutic concentrations of dabigatran. Some of these …
The effect of dabigatran on select specialty coagulation assays
DM Adcock, R Gosselin, S Kitchen… - American journal of …, 2013 - academic.oup.com
… In summary, dabigatran demonstrates an inhibitor effect in the hemostasis laboratory and
shows clinically significant interference in various clot-based and factor IIa–based chro-…
shows clinically significant interference in various clot-based and factor IIa–based chro-…
Impact of dabigatran on platelet function and fibrinolysis
AE Tsantes, E Kyriakou, S Bonovas… - Journal of the …, 2015 - Elsevier
… When we assessed the potential association between dabigatran levels (as determined by
the HTI assay) and hemostatic parameters, we detected very strong positive correlations with …
the HTI assay) and hemostatic parameters, we detected very strong positive correlations with …
[HTML][HTML] Global Thrombosis Test–a possible monitoring system for the effects and safety of dabigatran
K Otsui, DA Gorog, J Yamamoto, T Yoshioka, S Iwata… - Thrombosis …, 2015 - Springer
… dabigatran might affect shear-induced thrombi (occlusion time [OT], sec) by the GTT, and to
investigate the possibility that the GTT could be useful as a monitoring system for dabigatran. …
investigate the possibility that the GTT could be useful as a monitoring system for dabigatran. …
The anticoagulant effect of therapeutic levels of dabigatran in atrial fibrillation evaluated by thrombelastography (TEG®), Hemoclot Thrombin Inhibitor (HTI) assay and …
S Solbeck, AS Jensen, C Maschmann… - … Journal of clinical …, 2018 - Taylor & Francis
… hemostasis, may be used as a readily available screening test sensitive for the anticoagulant
effect of dabigatran … non-bleeding NVAF patients while displaying whole blood hemostasis. …
effect of dabigatran … non-bleeding NVAF patients while displaying whole blood hemostasis. …
The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the Hemoclot thrombin inhibitor assay in patient plasma …
G Hapgood, J Butler, E Malan… - … and haemostasis, 2013 - thieme-connect.com
… of the effect of dabigatran on coagulation assays is based on the analysis of dabigatran-…
ex vivo samples (ie plasma from patients receiving dabigatran) in contrast to in vitro plasma …
ex vivo samples (ie plasma from patients receiving dabigatran) in contrast to in vitro plasma …
Dabigatran effects on the international normalized ratio, activated partial thromboplastin time, thrombin time, and fibrinogen: a multicenter, in vitro study
WE Dager, RC Gosselin, S Kitchen… - Annals of …, 2012 - journals.sagepub.com
… increasing dabigatran concentrations. Commercial TT methods were very sensitive to low
concentrations of dabigatran, with 9 of 10 reporting sites exceeding test limits at dabigatran …
concentrations of dabigatran, with 9 of 10 reporting sites exceeding test limits at dabigatran …
Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
J Van Ryn, J Stangier, S Haertter… - … and haemostasis, 2010 - thieme-connect.com
… where complete haemostasis may be required dabigatran etexilate should be stopped 2–4
days before surgery. *Table 2 provides guidance for discontinuation of dabigatran etexilate …
days before surgery. *Table 2 provides guidance for discontinuation of dabigatran etexilate …
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