[HTML][HTML] Structural and functional basis of SARS-CoV-2 entry by using human ACE2
… domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2
(… binding mode similar overall to that observed for SARS-CoV. However, atomic details at the …
(… binding mode similar overall to that observed for SARS-CoV. However, atomic details at the …
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou - Science, 2020 - science.org
… COVID-19) epidemic. Here, we present cryo–electron microscopy structures of full-length
human ACE2 … spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 …
human ACE2 … spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 …
Structural variations in human ACE2 may influence its binding with SARS‐CoV‐2 spike protein
… by different human ACE2 allelic variants with SARS-CoV-2 spike protein. Briefly, coding
variants of ACE2 corresponding to the reported binding sites for its attachment with coronavirus …
variants of ACE2 corresponding to the reported binding sites for its attachment with coronavirus …
[HTML][HTML] Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
… Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells
… that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human …
… that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human …
[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis
… , compared to the one of the Bat-CoV to this receptor. The data presented in … SARS-Cov-2
spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2. …
spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2. …
[HTML][HTML] SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
… humans who have been hospitalized. Here, we evaluate transgenic mice expressing the
human angiotensin I-converting enzyme 2 (ACE2) … a model of SARS-CoV-2 infection. Intranasal …
human angiotensin I-converting enzyme 2 (ACE2) … a model of SARS-CoV-2 infection. Intranasal …
Does SARS-CoV-2 bind to human ACE2 more strongly than does SARS-CoV?
… In this paper we considered the interaction of S proteins with human ACE2 by combining
coarse-grained and all-atom steered molecular dynamics (SMD) simulations. All-atom models …
coarse-grained and all-atom steered molecular dynamics (SMD) simulations. All-atom models …
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
… of ACE2 are also being explored as cell entry inhibitors (34). Because human ACE2 has not
evolved to recognize SARS-CoV-2 S, … The coding sequence of full-length ACE2 with an N-…
evolved to recognize SARS-CoV-2 S, … The coding sequence of full-length ACE2 with an N-…
Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility
… involved in the SARS-CoV-2 S-protein interaction. Overall, we found human ACE2 receptor
… index) value of 0.0168, and the ACE2 PD showed even more reduced variation (Wilcoxon p…
… index) value of 0.0168, and the ACE2 PD showed even more reduced variation (Wilcoxon p…
Receptor and viral determinants of SARS‐coronavirus adaptation to human ACE2
… SARS coronavirus (SARS‐CoV). Here we identify the SARS‐CoV spike (S)‐protein‐binding
site on ACE2… S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and …
site on ACE2… S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and …
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