… , Ldlr −/− mice represent a moderate atherosclerosis model that develops lesions in a
time-dependent manner with site specificity. In addition, hyperlipidemia, … the Ldlr −/− mouse model …

… As certain characteristics of lipid metabolism in rats are in-between those of humans and
mice [9], we speculated that rat atherosclerosis models might have advantages compared to …

… fed a Western diet exhibit severe hyperlipidemia and develop significant atherosclerosis. …
deficiency on severe hyperlipidemia and atherosclerosis. Female LDLR −/− mice were lethally …

… The TgSREBP-1a;LDLR−/− mouse model is different from other hyperlipidemic animal
models because hepatic lipid overproduction, rather than simply a lack of lipoprotein clearance, …

… series of very useful mouse models to study hyperlipidemia and atherosclerosis. Normally,
mice carry … mice overexpressing APOC1 and lacking the LDLR. Indeed, the double transgenic …

… atherosclerosis is LDL receptor-deficient (LDLR −/− ) mice, which display mild hyperlipidemia
… We found that LDLR −/− mice were highly resistant to neointimal formation when they had …

… of LDLR−/− single mutants. We confirmed that HL−/− and wild-type mice did not develop
atherosclerosis … role in the enhanced atherosclerosis of HL−/−:LDLR−/− mice when compared to …

… , we transplanted renin-deficient bone marrow to irradiated Ldlr –/– mice and observed a
profound decrease in the size of atherosclerotic lesions. In similar experiments, transplantation …

… This study shows that sodium cholate is not necessary for the formation of atherosclerosis
in LDLR −/− mice and that precisely defined semipurified diets are a valuable tool for the …

… We hypothesized that diet-induced obesity and insulin resistance would increase atherosclerosis
in hyperlipidemic Ldlr −/− mice. In experiment 1, we used a high-fat diet containing lard…