… the relation or the impact of EGFR and KRAS mutations is yet to be … the frequency of EGFR
mutations and increased EGFR copy … of EGFR mutations with KRAS mutations because EGFR …

… Of these 339 patients, 180 with a completely resected lung adenocarcinoma, and whose
tumor harbored either KRAS codon 12 mutations or EGFR gene mutations within exons 18–21 …

… in exon 21 which was associated with depletion of the EGFR gene, we could not clearly
demonstrate an association between EGFR mutations and EGFR gene copy number. Cappuzzo …

… of KRAS mutations but also KRAS amplification is associated with acquired resistance to
the EGFR inhibitors cetuximab or panitumumab. We reasoned that KRAS amplification may …

… , KRAS wild-type tumors were not further classified by EGFR status, as EGFR mutations had
… Here, we sought to determine the prognostic significance of EGFR and KRAS mutations in …

… with KRAS mutations who had been treated with anti-EGFR … to evaluate the impact of
KRAS mutation subtype, together … other EGFR downstream genes, on the efficacy of anti-EGFR …

… WT groups due to potentially receiving targeted therapies in the second line of treatment,
we excluded all patients with EGFR mutations and ALK fusions in the KRAS WT group from …

… -sequencing, we found three cases with concomitant KRAS and EGFR mutations. Because
… the presence of KRAS mutations in minor clones can overcome the effect of EGFR mutations, …

… mutations within KRAS can predict resistance to anti-EGFR monoclonal antibodies. Activating
mutations in KRAS, which could result in EGFR-… These mutations are almost exclusively …

… In this study, we focused on the prognostic implications of EGFR mutation, not the predictive
implications. Therefore we excluded the patients who received gefitinib from the current …